49O - Downregulation of USP28 confers poorer overall survival to melanoma patients and causes resistance to RAF inhibitors

Date 05 March 2018
Event TAT 2018 - Targeted Anticancer Therapies
Session Proffered Paper Session 1
Topics Immunotherapy
Presenter Azad Saei
Citation Annals of Oncology (2018) 29 (suppl_3): iii7-iii9. 10.1093/annonc/mdy048
Authors A. Saei1, M. Palafox2, T. Benoukraf3, N. Kumari4, P. Iyengar3, Z.F. Bin Adam Isa3, H. Yang3, W.L. Tam1, V. Serra2, P. Eichhorn3
  • 1Genome Institute of Singapore, A*STAR, 138672 - Singapore/SG
  • 2Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, 08035 - Barcelona/ES
  • 3Cancer Science Institute of Singapore, 117599 - Singapore/SG
  • 4Biochemistry, National University of Singapore, 119228 - Singapore/SG


The mutation in BRAF kinase at V600 has been frequently reported in nearly 50% of melanoma patients resulting in the hyper-activation of MAPK pathway. As such, various inhibitors which target mutant BRAF have been developed including vemurafenib and dabrafenib both of which have demonstrated significant clinical outcomes. Nevertheless, both primary and acquired resistance reduce the overall response of patients to the therapy. So, the search of efficient biomarkers to stratify melanoma patients has become an imperative subject of research to enhance the efficacy of RAF inhibitor treatments and to decrease the rate of side effects due to the therapy. The mechanism of ubiquitination in controlling various functions such as stabilization of a protein cannot be neglected. A number of ubiquitin regulatory enzymes have been already shown to act on and regulate various component of MAPK pathway.