25IN - DNA and immunotherapy: Synergies of combinations

Date 06 March 2018
Event TAT 2018 - Targeted Anticancer Therapies
Session DNA targets: Damage, repair and immunotherapy
Topics Immunotherapy
Presenter Richard Kennedy
Citation Annals of Oncology (2018) 29 (suppl_3): iii1-iii6. 10.1093/annonc/mdy046
Authors R. Kennedy
  • -, Almac Diagnostics - GLOBAL & EU Headquarters, BT63 5QD - Craigavon/GB


In cancer the presence of T cell immune infiltration has been recognised as a prognostic factor, however the mechanisms underpinning this response are not clearly defined. Our group and others have identified a relationship between type I Interferon immune signalling and loss of DNA repair, particularly the Fanconi Anemia pathway, in several different types of cancer. We therefore investigated the mechanism activating this immune response in the context of abnormal DNA repair.