Prospective evaluation of PROMs and acute toxicity in VMAT planned radiotherapy for anal cancer and relation to planning constraints

Date 28 June 2017
Event ESMO World Congress on Gastrointestinal Cancer 2017
Session ESMO World Congress on Gastrointestinal Cancer 2017
Topics Gastrointestinal Cancers
Anal Cancer
Presenter Eva Serup-Hansen
Citation Annals of Oncology (2017) 28 (suppl_3): iii13-iii136. 10.1093/annonc/mdx261
Authors E. Serup-Hansen, A. Schouboe, A.C. Lefevre, E. Wilken, J. Hansen, L. Nyvang, K. Spindler
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The curative and organ preserving effect of Chemoradiotherapy (CRT) for anal cancer (AC) is well established. The treatment is, however, associated with significant acute and late toxicity. Advanced radiotherapy planning, such as IMRT and VMAT, have reduced dose to organs at risk and the consequential toxicity.


Studies on patient reported outcome measures (PROM) during and after CRT for AC are sparse and relation to dose planning constraints are unknown.


We prospectively collected acute toxicity data and PROMs during and 2-4 weeks after CRT for AC and correlated data to dose volume parameters for bowel and bladder.