The impact of different treatment modalities on toxicity and quality of life for prostate cancer - a real-world study based on WeChat in China

Date 24 November 2018
Event ESMO Asia 2018 Congress
Session Poster display - Cocktail
Topics Prostate Cancer
Complications/Toxicities of Treatment
Therapy
Presenter Xin Qi
Citation Annals of Oncology (2018) 29 (suppl_9): ix67-ix73. 10.1093/annonc/mdy434
Authors X. Qi1, H. Li2, S.X. Gao2
  • 1Radiotherapy Department, Peking University First Hospital, 100034 - Beijing/CN
  • 2Radiotherapy Department, Peking University First Hospital, Beijing/CN

Abstract

Background

To investigate the toxicity and quality of life (QOL) after different treatment modalities for prostate cancer in the real-world evidence in China based on WeChat.

Methods

WeChat is a very popular social APP in China which covered over 94% cellphone. The number of active users reaches 900 million every month, with the elderly exceeding 50 million. Electronic questionnaires were issued to prostate cancer patients of Beijing Anti-Cancer Association (BACA) through WeChat. Collecting the basic information, diagnostic information, TNM staging, treatment options and the adverse effects after treatment. The questionnaire was designed based on the EORTC C30 and PR25, mainly focusing on systemic reactions, urinary, rectal, hematology toxicity, and sexual function.

Results

A total of 393 questionnaires were collected. Radical surgery, external beam radiotherapy (EBRT), endocrine therapy, chemotherapy and particle implantation were conducted in 50.7%, 78.7%, 80.0%, 8.0% and 4.0% of the respondents, respectively. 93 (23.7%) patients reported significant impacts on their daily life. The most frequent (top 10) reported adverse effects were Fatigue (42.4%), defecate frequency (42.1%), leukaemia (39.4%), urinary frequency (31.6%), nocturnal increased (27.6%), anemia (20.2%), diarrhea (19.8%), urinary urgency (19.8%), sexual dysfunction (18.4%), and sleep loss (18.4%). The incidence of urinary incontinence and sexual dysfunction was higher after surgery than EBRT. While, urinary and bowel symptoms were reported more frequently in patients receiving EBRT. For treating these reactions, the first choice was traditional Chinese medicine, which was believed would improve the urinary and bowel function and ADT associated side effects in 41.3% of the respondents. The second popular method was Chinese food therapy which was recommended by 18.4% of patients. Anti-diarrhea drugs, such as Berberine and Smecta was usually used to relief rectal stimulation symptoms (26.7%).

Conclusions

Different treatments of prostate cancer had distinct impacts on patients’ QOL. Doctors should take this into consideration during decision making. The treatment for toxicities should get more attentions.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

Peking University First Hospital.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.