Study of the cellular immunity in children and adolescents with nasopharyngeal cancer

Date 24 November 2018
Event ESMO Asia 2018 Congress
Session Poster display - Cocktail
Topics Tumour Immunology
Cancers in Adolescents and Young Adults (AYA)
Head and Neck Cancers
Presenter Nargiza Karimova
Citation Annals of Oncology (2018) 29 (suppl_9): ix94-ix104. 10.1093/annonc/mdy438
Authors N.M. Karimova1, D.S. Polatova2, A. Ismailova3, I. Iskandarova4, M. Boboev1
  • 1Pediatric Medical Oncology, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
  • 2Bone And Soft Tissue Sarcomas, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
  • 3Administration, Institute of Immunology, 100060 - Tashkent/UZ
  • 4Oncology And Radiology, Tashkent Medical Academy, 100102 - Tashkent/UZ

Abstract

Background

In this study we aimed to study the cellular link of the adaptive immune response in nasopharyngeal cancer in children and adolescents.

Methods

We examined 36 children and adolescents with nasopharyngeal tumors who were on combined treatment at The Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan from 2016-2018. The control group included 29 healthy children of the same age and sex.

Results

A study of the relative content of lymphocytes revealed a significant suppression of the total number of lymphocytes in the group of patients with nasopharyngeal cancer when compared with the control group (p < 0.05). Analysis of immunophenotype of T-lymphocytes in children showed a significant decrease in CD3 + expression on T-lymphocytes and its absolute value in comparison with the values of the control group (p < 0.05). The obtained results showed that in children, a significant decrease in CD4 + expression on T-lymphocytes was observed in comparison with the control group values (in children, the CD4 + T-helper/inducer number averaged 25.9±2.4%, compared with 34.6±1.3% in the control group (p < 0.05). Analysis of the natural killer cells (NKC) subpopulation by membrane immunophenotype - CD16 revealed a significant increase in the relative amount of CD16 + NKC in the group of sick children and was 22.8±1.22%, while in the control group this figure was 18.6±0.9%. A study of CD20 + B-lymphocyte counts revealed a significant increase in the relative number of CD20 + B-lymphocytes in patients with children and was 22.9±1.2%, and in the control group 18.4±0.58% (p < 0.05). CD38 + expression in patients was 26.8 ±1.4%, and in the control group - 22.6±0.8% (p < 0.05).

Conclusions

In the case of nasopharyngeal cancer, characteristic changes in the cellular link of adaptive immunity are observed in children and adolescents, which were manifested by suppression of CD3 + T-lymphocytes, CD4 + T-helper/inducers, immunoregulatory index, CD8 + T-cytotoxic lymphocyte count, CD16 + cells, as well as an increase in the expression of CD38 + and CD95 + on lymphocytes.

Editorial acknowledgement

Clinical trial identification

Legal entity responsible for the study

The Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.