Multimodality, aggressive and sustainable care in metastatic osteosarcoma: A tertiary care cancer experience from India

Date 25 November 2018
Event ESMO Asia 2018 Congress
Session Mini Oral - Melanoma and Sarcoma
Topics Cancer Care Delivery in Low Resource Environments
Therapy
Presenter Jyoti Bajpai
Citation Annals of Oncology (2018) 29 (suppl_9): ix124-ix128. 10.1093/annonc/mdy443
Authors J. Bajpai1, V. Simha1, A. Chandrashekharan1, J. Ghosh1, B. Rekhi2, T. Vora1, S. Banavali1, S. Gupta1
  • 1Medical Oncology, Tata Memorial Centre, 400012 - Mumbai/IN
  • 2Pathology, Tata Memorial Centre, 400012 - Mumbai/IN

Abstract

Background

Metastatic osteosarcoma outcomes are dismal, despite costly and complex high-dose methotrexate (HDMTX)–based therapies. This is challenging especially in lower and middle-income countries (LMICs) with limited resources & increasing patient volumes. We need to reallocate resources to efficient but sustainable strategies, like exploring Non-HDMTX based protocols and aggressive multimodality approach in this setting.

Methods

All consecutive treatment-naïve patients with metastatic osteosarcoma were prospectively treated on the “OGS-12” protocol, which involved administration of eight sequential doublets of the three most active drugs (doxorubicin, cisplatin, and ifosfamide), universal growth factor prophylaxis and targeted nutritional support if required. Four cycles were administered as neoadjuvant therapy (NACT) followed by planned curative intent surgery and metastasectomy when feasible, followed by four cycles of adjuvant chemotherapy (ACT).

Results

Four ninety-five patients were enrolled in the OGS-12 protocol from 2011 to 2016, of whom 110 (22%) had metastatic disease; the median age was 17 years. The majority of patients were nutritionally challenged with high-risk features like high LDH (80%), high SAP (91%). After NACT, 57% of patients were histologically good responders (gHR) that is ≥ 90% tumor necrosis. Five-year event-free survival (EFS) & overall survival(OS) rates were 24% & 20%, respectively, in the intent-to-treat and 43% & 29%, respectively, in the per-protocol populations. Significant grade 3/4 toxicities were febrile neutropenia (29%), thrombocytopenia (39%), and anemia (56%). Ability to perform metastectomy for improved OS, compliance to therapy for improved EFS, and gHR for both improved EFS and OS were identified as independent prognostic markers.

Conclusions

Adoption of an aggressive multimodality approach including the novel, low-cost, Non-HDMTX–based, dose-dense "OGS-12" protocol, enhanced supportive care & compliance, with metastectomy resulted in internationally comparable outcomes of metastatic osteosarcoma patients. This rational and sustainable, economically efficient strategy is worthy of wide adaption.

Editorial acknowledgement

Legal entity responsible for the study

Dr Jyoti Bajpai, Tata Memorial Cancer Center.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.