A randomized study comparing two different training programs

Date 24 November 2018
Event ESMO Asia 2018 Congress
Session Poster display - Cocktail
Topics Supportive Measures
Presenter Anne Bellens
Citation Annals of Oncology (2018) 29 (suppl_9): ix129-ix138. 10.1093/annonc/mdy444
Authors A. Bellens1, B. Sabbe2, P. van Dam3
  • 1Onco-gynaecology, University of Antwerp-Campus Drie Eiken, 2650 - Edegem/BE
  • 2Psychiatry, University of Antwerp-Campus Drie Eiken, 2650 - Edegem/BE
  • 3Onco-gynaecology, University Hospital Antwerp,UZA, 2650 - Edegem/BE

Abstract

Background

Even mild cognitive dysfunction can have profound impact on professional, social and psychological functioning in cancer survivors. Up to date no therapeutic intervention, besides cognitive behavior therapy and mindfulness, has proven to improve this problem. Cognitive testing is rarely performed in mild cognitive impairment. The effect of playing an online video game was investigated on various cognitive domains (attention, psychomotor speed, episodic memory, working memory and executive function), as well as on perception of quality of life, anxiety and depression, cognitive failure, sleep and cognitive insight.

Methods

46 patients of the breast cancer-unit of the Antwerp University Hospital complaining of chemo-brain voluntarily enrolled between august 2016 and october 2017. Aged 18-70 years, without brain metastasis, signs of dementia, or severe hearing- or vision impairment. They were randomized in two groups: group A (N = 23) played a videogame “Aquasnap” (MyCognition, London, UK) for 6 months and 90 minutes per week. Group B (N = 23) started the same video game after a waiting period of 3 months and played for 3 months. All patients performed online cognitive testing at home with “MyCQ Med” provided by the same company, on a monthly basis. Psychometric testing was offered at onset, 3 and 6 months using RAND 36, Hospital Anxiety and Depression Scale, Cognitive Failure Questionnaire, Pittsburgh Sleep Quality Index and Beck Cognitive Insight Scale.

Results

Both groups showed a significant (p < 0.05) improvement in cognitive testresults (episodic memory, processing speed, working memory, executive function and attention), anxiety, sleep latency time, mental and cognitive health perception, vitality, quality of life, from onset to endpoint. Both groups showed deterioration of self-reflection. There was no difference between the two groups in objective cognitive testing, cognitive insight, perception of anxiety, depression, sleep quality, cognitive failure nor overall well-being.

Conclusions

Both interventions had and an apparent effect on cognitive functioning. Overall a significant improvement of anxiety, vitality, sleep and cognitive perception was documented.

Editorial acknowledgement

Clinical trial identification

B300201627683.

Legal entity responsible for the study

\"Comite voor Methisch Ethiek\", Antwerp University Hospital, Belgium.

Funding

University Hospital Antwerp, Multidisciplinary Oncology Centre Antwerp, Belgium (MOCA), MyCognition, Ltd, London, United Kingdom.

Disclosure

All authors have declared no conflicts of interest.