495P - Treatment of Cutaneous Kaposi Sarcoma with Chemo-Radiotherapy Vs Chemotherapy, in HIV Positive Patients- A Retrospective Study. (495P)

Date 18 November 2017
Event ESMO Asia 2017 Congress
Session Poster lunch
Topics Cytotoxic agents
Cancer in Special Situations
AIDS-Associated Malignancies
Skin cancers
Surgical oncology
Therapy
Biological therapy
Radiation oncology
Presenter KABILAR VENUGOBAL
Citation Annals of Oncology (2017) 28 (suppl_10): x149-x152. 10.1093/annonc/mdx675
Authors K. VENUGOBAL
  • Oncology, cancer instirute, 600032 - chennai/IN

Abstract

Background

This study aimed to compare the treatment outcomes in AIDS associated cutaneous Kaposi sarcoma, among the patients who received both chemoradiation vs chemotherapy only, in terms of CR, PR, and recurrence rates.

Methods

This study included 40 patients, who were diagnosed to have AIDS associated cutaneous Kaposi sarcoma [Endemic (African) Kaposi sarcoma] and treated during the period from June 2013 to June 2016. The study included 2 arms (arm A & arm B). Arm A comprises 20 patients who were diagnosed to have cutaneous Kaposi sarcoma and treated with chemotherapy followed by external beam radiotherapy, and arm B comprises 20 patients who were diagnosed to have cutaneous Kaposi sarcoma and treated with chemotherapy only for the same period of time. In arm A, a total of 20 patients were irradiated after chemotherapy, as follows: face 2 (10%), trunk 3 (15%), upper and lower limbs 14 (70%), and oral cavity 1 (5%). In arm B, a total of 20 patients received only chemotherapy and their site distribution of lesions were as follows: face 4 (20%), trunk 2 (10%), upper and lower limbs 13 (65%), and face, oral cavity & shoulders 1 (5%).

Results

Treatment outcomes in both arms were compared in terms of clinical response (CR), pathological response (PR) and the recurrence rates. Among the 20 patients in arm A who received chemotherapy followed by radiotherapy for cutaneous Kaposi sarcoma, 19 patients had complete clinical response (p value - 0.01) and these patients are still under follow up, and one patient had recurrent cutaneous lesion in his same lower limb, whereas in arm B in which 20 patients who were treated with chemotherapy alone during the same period, 6 patients had clinically diagnosed utaneous Kaposi sarcoma lesion and 3 patients had pathological recurrent lesion in the same site or other sites and 1 patient presented with lung metastasis. Patients with cutaneous Kaposi sarcoma in both arms responded to their treatment but there was a significant difference in recurrence rates in both arms.

Conclusions

Patients in arm A who received chemotherapy followed by radiotherapy among the 20 patients only one patient had recurrent lesion (p value 0.01) and whereas in Arm B among the 20 patients 10 patients had recurrence or distant metastasis. Odds Ratio 0.06, 95% Confidence Interval: 0.01- 0.41, p value 0.01). This study proves that i cutaneous Kaposi sarcoma there is better complete clinical response and a decrease in recurrence and distant metastasis with the patients who receives chemotherapy followed by external beam radiotherapy, compared with the patients who received chemotherapy only.

Clinical trial identification

Legal entity responsible for the study

Dr. Kabilar Venugobal

Funding

None

Disclosure

All authors have declared no conflicts of interest.