258P - Comparison of results of cytological and hystological research of thyroid gland nodes (258P)

Date 18 November 2017
Event ESMO Asia 2017 Congress
Session Poster lunch
Topics Thyroid Cancer
Endocrine Cancers
Pathology/Molecular Biology
Basic Scientific Principles
Presenter Saodat Issaeva
Citation Annals of Oncology (2017) 28 (suppl_10): x57-x76. 10.1093/annonc/mdx660
Authors S.S. Issaeva1, Z. Khalimova2, S. Ismailov3, A. Yuldashev4, F. Yuldasheva1
  • 1Science, Republican Specialized Scientific and Practical Medical Center of Endocrinology Uzbekistan, 100125 - Tashkent/UZ
  • 2Neuroendocrinology, Republican Specialized Scientific and Practical Medical Center of Endocrinology Uzbekistan, 100125 - Tashkent/UZ
  • 3Surgery, Republican Specialized Scientific and Practical Medical Center of Endocrinology Uzbekistan, 100125 - Tashkent/UZ
  • 4Histology, Tashkent Medical Academy, 100125 - Tashkent/UZ

Abstract

Background

Purpose: to assess the sensitivity and specificity of the cytomorphological method in the diagnosis of the nosological variant of nodal goiter

Methods

Materials and methods: a comparison of the results of cytological and histological studies of thyroid nodules in 36 patients (15 women and 11 men, average age 54.2 ± 9 years), operated for nodular goiter. Cytological findings were divided into 4 categories: “non-informative material”, “benign lesion”, “follicular neoplasia”, “malignant formation”.

Results

the analysis of the results of cytological research showed that 17 (47.2%) cases were given the conclusions “non-informative material”, 14 (38.9%) “benign lesion”, in 5 (13.9%) - “follicular neoplasia”, and not a single conclusion “malignant formation”. According to the results of histological examination, in 10 (58.8%) cases, colloidal proliferating nodes were diagnosed in different categories, in 6 (35.3%) - follicular adenoma, in 1 (5.9%) - papillary cancer. Among the conclusions of the category “benign lesion” in 9 (64.3%) cases, according to the results of histological examination, colloidal proliferative nodes in different degrees were diagnosed, in 5 (35.7%) - follicular adenoma. Among the conclusions of the category “follicular neoplasia” in 3 (60%) cases - follicular adenoma, in 1 (20%) - colloidal proliferative nodes in different degrees, in 1 (20%) - papillary cancer. The sensitivity of the cytomorphological method of diagnosis of “nodular colloid goiter” was 44%, specificity-69%, “follicular neoplasia” 20% and 91%.

Conclusions

the results of the study showed a high percentage of the conclusions of the category “non-informative material” and identified malignant formations in this category, which significantly reduces the sensitivity of the cytomorphological diagnostic method at the preoperative stage with nodular goiter and requires unification and optimization of both FNA and cytological classification.

Clinical trial identification

Legal entity responsible for the study

Ismailov S.I.

Funding

None

Disclosure

All authors have declared no conflicts of interest.