544P - The number of negative lymph node was an indicator on the extent of lymphadenectomy in middle thoracic esophageal squamous cell carcinoma

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Oesophageal Cancer
Surgery and/or Radiotherapy of Cancer
Presenter Jinling Zhang
Citation Annals of Oncology (2016) 27 (suppl_9): ix177-ix178. 10.1093/annonc/mdw600
Authors J. Zhang
  • Linyi People Hospital, Cancer Center, Shandong University School of Medicine, 276000 - Jinan/CN

Abstract

Background

It was controversial on the extent of lymphadenectomy in patients with middle thoracic (ESCC). The number of negative lymph node (LN) removed in operation was also a prodictor for overall survival (OS) of patients with ESCC, but it was not clear whether the number of negative LN could be used for an indicator on the extent of lymphadenectomy.

Methods

A retrospective analysis on the 208 patients with middle thoracic ESCC was performed, who experienced esophagectomy and lymphadenectomy at our hospital between Jan 2009 and Jan 2013 without neoadjuvant chemoradiotherapy. The relation between clinical parameters and the number of positive or negative LNs was explored using the χ2 test, and futhermore factors selected from the χ2 test were put into a forward stepwise Cox regression model to identify significant prognostic factors. Survival analysis using Kaplan-Meier method was performed to test those prognostic factors. The cut-off number of negative LN was explored using a series of logrank tests.

Results

Close relation between the number of positive LN and tumor site, tumor differentiation, depth of tumor invasion, nerve inasion, lymph vessel invasion were confirmed, while only the close relation between the number of negative LN and lymph vessel invasion was identified (P = 0.03). The analysis result in Cox regression model revealed that the T stage of tumor, the number of positive LN, and the number of negative LN were significant prognostic factors (P < 0.031, P < 0.001, P = 0.001, respectively). The result of the series analysis using logrank tests identified that it might a reasonable range for lymphadenectomy in middle thoracic ESCC which removed more than 6 and less than 20 negative LNs in operation.

Conclusions

The number of negative LN resected in operation could give an indication on the range of lymphadenectomy in thoracic ESCC.

Clinical trial indentification

Legal entity responsible for the study

Jinling Zhang

Funding

Natural Science Foundation of Shandong Province, China

Disclosure

All authors have declared no conflicts of interest.