117PD_PR - Survival benefit of surgical removal for the primary tumor in stage IV breast cancer patients

Date 19 December 2016
Event ESMO Asia 2016 Congress
Session Breast cancer
Topics Breast Cancer, Metastatic
Surgical Oncology
Presenter HYE JIN Kim
Citation Annals of Oncology (2016) 27 (suppl_9): ix35-ix41. 10.1093/annonc/mdw577
Authors H.J. Kim1, E. Kang1, E. Kim2, Y. Jang1
  • 1General Surgery, Seoul National University Bundang Hospital, 82 - Seoul/KR
  • 2General Surgery, Seoul National Unversity Bundang Hospital, 82 - Seoul/KR



Several studies have suggested that primary tumor removal improved overall survival in stage IV breast cancer. However, survival benefit of local treatment still remains controversial. The purpose of this study is to determine whether surgical removal of the primary tumor provides survival benefits for stage IV breast cancer.


We retrospectively reviewed the records of 157 patients who were diagnosed with stage IV breast cancer initially at Seoul National University Bundang Hospital between 2003 and 2015. The Kaplan Meier analysis was used for estimation of median survival. The log-rank test was used to compare differences according to patient and tumor characteristics. Multivariate cox regression analysis for survival was used for controlling potential confounding variables.


Of 157 stage IV breast cancer patients, 97 patents (62%) underwent surgical removal for primary tumor. The median survival was longer for patients who had better response of chemotherapy (70 vs. 47 months, p = 0.023) and surgery (118 vs. 28 months, p 


Our results showed that the primary tumor removal and good chemo-response were associated with improvement in better survival. Therefore, surgical management for the primary tumor should be considered more actively in stage IV breast cancer patients.

Clinical trial indentification

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All authors have declared no conflicts of interest.