342P - Social impact of pediatric acute myeloid leukaemia (AML) is biggest challenge in eastern India – A demographic, clinical and psychological study

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Leukaemia
Psychosocial Aspects of Cancer
Cancer in Special Situations
Presenter Minakshi Sen
Citation Annals of Oncology (2016) 27 (suppl_9): ix104-ix111. 10.1093/annonc/mdw586
Authors M. Sen, A. Datta, A. Mukhopadhyay
  • Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 700016 - Kolkata/IN

Abstract

Background

Pediatric Acute Myeloid Leukemia (AML) is becoming an emerging health challenge in eastern India thus affecting not only physical growth of children but also their mental well being. An observational study was conducted in a tertiary cancer centre of Eastern India to find out the association between clinical and psychological parameters of pediatric AML patients. However, a comparison was also drawn with healthy children of the same family.

Methods

During May 2014 - July 2016, total 87 pediatric AML patients (53 male and 34 female) aged between 4-15 years attended OPD of Netaji Subhas Chandra Bose Cancer Research Institute, were studied for physical and mental status. Age and sex matched 43 healthy children (age range: 4- 15 years) from these affected families were also included as control group. Demographic factors (age, sex etc.) and clinical parameters (CBC, Electrolyte Analysis, RFT, and LFT etc.) were collected from hospital records. Behavior pattern was assessed by using Child Behavior Checklist from parents. We have compared those factors according to treatment plan. Finally, clinical parameters and behavioral pattern were compared between patients and healthy group.

Results

The overall survival in 2 year was 70.2% in patients aged ≤15 years (with mean age 11.2 years). The ratio between patients and control group was 2.02:1. 28.1% of patients experienced developmental decline. Abnormal performance status, CBC, Electrolyte Analysis, RFT, LFT etc. were associated with increased likelihood of developmental decline. In addition, patients undergoing chemotherapy had shown significant decline in above mentioned factors than non chemo patients. Significant difference among demographic and clinical parameters and psychological factors were seen.

Conclusions

Our unique findings emphasize that the intensity and extent of treatment with chemotherapy may disrupt psychological/psychosocial development as well as electrolyte imbalance and liver and renal dysfunction of pediatric AML patients.

Clinical trial indentification

NA

Legal entity responsible for the study

N/A

Funding

Netaji Subhas Chandra Bose Cancer Research Institute

Disclosure

All authors have declared no conflicts of interest.