245P - SOX15 expression was associated with poor prognosis in patients with esophageal squamous cell carcinoma: An Iranian cohort study conducted over 10...

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Oesophageal Cancer
Translational Research
Presenter soodabeh Shahidsales
Citation Annals of Oncology (2016) 27 (suppl_9): ix68-ix85. 10.1093/annonc/mdw582
Authors S. Shahidsales1, A. Moradi2, F. Ghasemi2, K. Anvari3, S. Ahmadi-Simab4, M.M. Forghanifard5, M.T. Boroushaki6, A. Avan2
  • 1Radiotherapy Oncology, Mashhad University of Medical Sciences-Omid Hospital Cancer Research Center, 000000000 - Mashhad/IR
  • 2Department Of Modern Sciences And Technologies, Mashhad University of Medical Sciences, 000000000 - Mashhad/IR
  • 3Radiation Oncology, Mashhad University of Medical Sciences-Omid Hospital Cancer Research Center, 9176613775 - Mashhad/IR
  • 4Cancer Research Center, Mashhad University of Medical Sciences-Omid Hospital Cancer Research Center, 000000000 - Mashhad/IR
  • 5Department Of Biology, Islamic Azad University, 0000000001 - damghan/IR
  • 6Department Of Pharmacology And Pharmacological, Mashhad University of Medical Sciences, 000000000 - Mashhad/IR

Abstract

Background

WNT/B-CATENIN signaling pathway is one of the key dysregulated pathways in esophageal squamous cell carcinoma (ESCC), which has been reported to be modulated by sex-determining region Y-box (SOX) family genes. SOX15 is recently been identified as a novel tumor suppressor in pancreatic cancer with a potential role in modulating Wnt/b-catenin signaling. The aim of current study was to explore, for the first time, the expression pattern of SOX15 in an Iranian patient cohort with ESCC.

Methods

Data in computer-based patient records (CPRs) of Mashhad University of Medical Sciences were used to retrieve all ESCC patients, during July 2004 to September 2014, from Khorasan providence, the second big providence of Iran. Based on the available tissue, one hundred and eight patients were recruited for current study. The stained sections were micro-dissected under a microscope, followed by RNA extraction. The expression pattern of Sox15 was evaluated by real time RT-PCR. Demographic and clinical information were compared across genotype using Pearson tests. OS and PFS curves were analyzed according to Kaplan–Meier method, and compared by log-rank and Wilcoxon tests. The significant prognostic variables in the univariate analysis were included in multivariate analyses, using Cox’s proportional hazards model

Results

Our data showed that patients with low mRNA expression of SOX15 had statistically significantly shorter survival (eg, mean = 43.5 months, 95% confidence interval [CI] = 4.4 to 52.6; vs mean=58.1 months, 95% CI = 56.2 to 80.1; P = 0.04, two-sided log-rank test), and multivariable analyses confirmed prognostic relevance of this marker in the patient. In particular, SOX15 downregulation was significantly associated with risk of death (hazard ratio, HR = 1.6, 95% confidence interval [CI], 1.2–2.6) in our population.

Conclusions

These results define SOX15 as a novel prognostic factor for ESCC. Further functional analysis is warranted to determine its tumor-suppressor role in ESCC

Clinical trial indentification


Legal entity responsible for the study

N/A

Funding

Mashhad University of Medical Sciences

Disclosure

All authors have declared no conflicts of interest.