155P - Randomized controlled trial of CT-guided versus laparoscopic radiofrequency ablation in recurrent small hepatocellular carcinoma against the diaphr...

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Hepatobiliary Cancers
Surgical Oncology
Presenter QIN Zheng
Citation Annals of Oncology (2016) 27 (suppl_9): ix46-ix51. 10.1093/annonc/mdw579
Authors Q. Zheng1, H. Ding2, C. Zhu1, L. Wang2, Y. Wan3
  • 1Oncology, the second hospital affiliated to southeast university, 210003 - nanjing/CN
  • 2Radiology, the second hospital Affiliated to Southeast University, 210003 - Nanjing/CN
  • 3Biomedical, Pennsylvania State University, 16801 - University Park/US



Radiofrequency ablation (RFA) have been used to treat hepatocellular carcinoma (HCC) in the subphrenic area. Very few studies focus on ablation of recurrent small HCC against the diaphragmatic dome. The therapeutic safety, efficacy, and hospital fee have never been compared between CT guided RFA and laparoscopic RFA (L-RFA) either.


CT guided RFA and L-RFA were performed in totally 116 patients with 151 local recurrent HCC lesions abutting the diaphragm. We compared major and minor postoperative complications, hospital stay and fee, overall survival (OS), and local tumor progression (LTP) between two groups for evaluating respective therapeutic efficacy and safety. Moreover, in CTguided percutaneous RFA group, depending on the locations of recurrent HCC nodules differentiated puncture paths and ablation methods were used, and intraoperative complications were recorded


There is no significant difference in OS and LTP between CT-guided RFA and LRFA.In recorded postoperative complications, the morbidity in CT-guided RFA group is lower than that of L-RFA group. The average safety margin is 8 and 11 mm in CT-guided RFA and LRFA group, respectively. The shoulder and back pain is significantly high in L-RFA group probably due to pneumoperitoneum. Moreover, overall hospital stay and cost is also lower in CT-guided RFA group.


Both CT-guided RFA and L-RFA are considered to be an effective approach for recurrent small HCC abutting diaphragm. Particularly, CT-guided RFA is an easy and economic with less complications if suitable puncture paths and ablation methods can be applied.

Clinical trial indentification

Legal entity responsible for the study

Huaiyin Ding, Chuandong Zhu, Lixue Wang, Qin Zheng, and Yuan Wan


This work was partially supported by Nanjing Medical and Health Research Funding YKK15142, Natural Science Foundation of Jiangsu Province BK20141084, Key Topics of Nanjing Medical Technology Development Project (ZKX13019), and Medical Research Program of Jiangsu Province H201440.


All authors have declared no conflicts of interest.