77P - Menarche age, contraception use and gravidity as risk factors for breast cancer: Associations in a case-control study

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Breast Cancer, Early Stage
Presenter Dariush Moslemi
Citation Annals of Oncology (2016) 27 (suppl_9): ix19-ix29. 10.1093/annonc/mdw575
Authors D. Moslemi1, M. Ghanbari2, S. Esmaelzade1, M. Agajani Delavar1
  • 1Gynecology, Babol University of Medical Sciences (BUMS), 47176-47745 - Babol/IR
  • 2Gynecology, Babol University of Medical Sciences (BUMS), 47167-98467 - Babol/IR

Abstract

Background

high incidence of Breast cancer (BC) in recent years has been considered as a major problem of female's health. We aimed to share our experience for focusing on some of risk factors for (BC) among patients who referred to Shahid Rajai radiotherapy center Babolsar, Mazandaran, Iran

Methods

A Case-Control study of (BC) obtained from patients who referred to Shahid Rajai radiotherapy center in babolsar. A total of 810 cases with histologically confirmed BC between September 2012 and February 2015 were enrolled. Controls, N = 840, were matched frequency to cases by 5-year age group. Data from both groups by questionnaire was collected. To assess associations between each risk factor and BC risk logistic regression applied with 95% confidence intervals and adjusted odds ratios

Results

The mean age of case and control group was 46.57±8.33 and 46.99±9.94 years, moreover the mean age of menarche in case and control group was 11.83±1.34 and 12.00±0.44 years, respectively. In multivariable models, Menarche age (OR = 4.04, 95% CI: 2.48 -6.59), gravidity (OR = 0.18, 95% CI: 0.13-0.24), and contraception use history (OR = 6.04, 95% CI: 4.71-7.76) were the strongest predictors of BC in our study population

Conclusions

Nulligravidity and high duration of using contraception are Modifiable factors that women can modify them and lower age of menarche also had a strong association with (BC).

Clinical trial indentification

Legal entity responsible for the study

Babol University of Medical Sciences

Funding

Babol University of Medical Sciences

Disclosure

All authors have declared no conflicts of interest.