351P - Clinico-pathologic profile and clinical outcomes of patients with indolent lymphoma at the Cancer Institute of the Philippine General Hospital: A 7...

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Lymphomas
Presenter Paolo Dela Rosa
Citation Annals of Oncology (2016) 27 (suppl_9): ix104-ix111. 10.1093/annonc/mdw586
Authors P.R. Dela Rosa1, C.V. Uy1, J. Tindoc2, C. Ngelangel1
  • 1Medicine, Philippine General Hospital, 1000 - Manila/PH
  • 2Pathology, Philippine General Hospital, 1000 - Manila/PH

Abstract

Background

Indolent lymphoma (IL) is a slowly growing lymphoma, generally refractory to conventional chemotherapy. There are several types of IL, which includes Follicular lymphoma, Marginal Zone lymphoma, Small Lymphocytic lymphoma, Mantle Cell lymphoma, and Waldenstrom Macroglobulinemia/Lymphoplasmacytic lymphoma. Presently, there are no known data in the Philippines on IL. This study is done to determine the clinico-pathologic profile and outcomes of Filipino patients with IL.

Methods

This study is a retrospective chart review of outpatient department cases of IL seen at the Philippine General Hospital-Cancer Institute from January 2009 to January 2016. The following were documented: age; gender; initial complaint; presence or absence of B symptoms; sites involved; type of IL; Ann-arbor stage; prognostic indices for FL and MCL; and if bone marrow aspiration or complete whole body CT scan were done as part of initial staging. Treatment intervention and clinical outcomes were documented. Fischer’s exact test at p 

Results

This study showed that Small Lymphocytic lymphoma was the most common IL. Most were elderly (>40 years old); male; without B symptoms; limited disease; and initial complaint related to the eye. MCL were seen in all risk groups, and positive for cyclin D1; FL were mostly grade 1, and positive for BCL2 and CD10. Majority had disease control regardless of treatment intervention. Most patients with recurrence/progression after initial treatment had limited disease and incompletely staged. There seemed to be no association between age, gender, stage, complete whole body CT scan/bone marrow aspiration with clinical outcomes, although the sample size examined was small.

Conclusions

Results of this study are mostly consistent with known literature on IL. Absence of B symptoms and limited disease may indicate a low-grade histology. Observation remained the intervention of choice for patients who were asymptomatic.

Clinical trial indentification

Legal entity responsible for the study

Paolo R. dela Rosa

Funding

Self-funded by the authors

Disclosure

All authors have declared no conflicts of interest.