474P - Clinical features of intradural extramedullary spinal cord metastases in primary lung cancer

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Metastatic
Presenter Yan Xu
Citation Annals of Oncology (2016) 27 (suppl_9): ix139-ix156. 10.1093/annonc/mdw594
Authors Y. Xu, W. Zhong, J. Zhao, M. Chen, L. Li, M. Wang
  • Department Of Respiratory Medicine, Peking Union Medical College Hospital, 100730 - Beijing/CN

Abstract

Background

Intradural extramedullary spinal cord metastases in lung cancer is rare, and it leads to severe neurological damage. The purpose of this study was to identify the clinical features of intradural extramedullary spinal cord metastases in primary lung cancer patients.

Methods

8 cases of lung cancer with intradural extramedullary metastases, who were hospitalized in Peking Union Medical College Hospital (PUMCH) during May, 2013 to May, 2016, wereenrolled in the retrospective study. Medical charts of the 8 patients were reviewed systematically.

Results

Intradural extramedullary spinal cord metastases was diagnosed in 7 cases with non-small cell lung cancer (NSCLC) and 1 case with small cell lung cancer (SCLC). Cauda equina syndrome was the most common clinical manifestation. Malignant cells in cerebrospinal fluid were positive in all the 5 cases (100%) who underwent lumbar puncture. Contrast-enhanced magnetic resonance imaging (MRI) of spine manifested as diffuse abnormal enhancement of pial lining of spinal cord in 3 cases, intradural extramedullary nodules in 4 cases, and both of themin 1 case. Neurological symptoms were improved or stable in 4 cases who underwent targeted therapy and/or radiotherapy. The median overall survival was 5.8 months (95%CI, 1.9-9.6m). Table: Clinical characteristics and treatment outcomes of patients with intradural extramedullary spinal metastasis

Conclusions

Intradural extramedullary spinal cord metastases canbe diagnosed with caution according to its neurological symptoms and contrast-enhanced MRI presentation. Targeted therapy and/or radiotherapy may be effectivefor symptoms control.

Clinical trial indentification

Legal entity responsible for the study

Peking Union Medical College Hospital

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.