319P - Choriocarcinoma: A 10 year tertiary care cancer hospital experience

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Gynaecological Malignancies
Presenter Samia Yasmeen
Citation Annals of Oncology (2016) 27 (suppl_9): ix94-ix103. 10.1093/annonc/mdw585
Authors S. Yasmeen
  • Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Reserch Centre (SKM), 54550 - Lahore/PK

Abstract

Background

Gestational chorio-carcinomas are highly malignant tumors of trophoblastic tissue occuring during or after pregnancy. Very little data is available in Pakistan.

Methods

Patients diagnosed as choriocarcinoma managed at Shaukat Khanum Cancer hospital, Lahore, Pakistan from 2005 to 2015 were included. Data was recorded on age, risk scoring, pre and post-operative B-human chorionic gonadotropins (B-hCG) levels, treatment, type and number of chemotherapy cycles, type of surgery and overall survival (OS). OS by Kaplan Meier method was the interval between the date of diagnosis and last visit/death.

Results

Thirty eight patients with choriocarcinoma with median age of 25 years were included. Using FIGO staging, stage 1 was identified in 7, II in 1, III in 14, IV in 8 and unknown in 8 patients respectively. Pre-treatment Beta-hCG ranged from 28 to 921000 ug/l. Twenty-seven patients (71.0%) had high risk category, 7 (18.4%) in medium risk and 4 (10.5%) had low risk. EMA-CO was the most common initial regimen (35 patients). Four patients, as non-responders to EMA-CO, were later on treated by EP-EMA protocol. Median number of chemotherapy cycles was 6. Mean time to normalization of Beta-hCG was 7.26 + 2.24 weeks. Thirty three patients completed all chemotherapy cycles. Post treatment Beta-hCG levels normalized in all patients except four nonresponders to EMA-CO; however disease was not controlled in these patients. Thirty three patients achieved complete response. Five patients expired, while 3 were lost to follow up after treatment. Thirty out of 38 patients were alive at median follow up of 52 months. Median survival by Kaplan Meier method was yet not reached.

Conclusions

Choriocarcinoma is a curable malignancy and chemotherapy can achieve high cure rates and inadvertent surgery should be avoided in all cases unless deemed necessary.

Clinical trial indentification

Legal entity responsible for the study

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Funding

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Disclosure

All authors have declared no conflicts of interest.