97P - Cardiac arrhythmia is highly associated with breast cancer compared to benign breast disease

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Breast Cancer, Early Stage
Presenter Seung Pil Jung
Citation Annals of Oncology (2016) 27 (suppl_9): ix19-ix29. 10.1093/annonc/mdw575
Authors S.P. Jung1, J.W. Bae1, S. Oh2, J. Choi2, Y. Kim2
  • 1Surgery, Korea University Anam Hospital, 02841 - Seoul/KR
  • 2Internal Medicine, Korea University Anam Hospital, 02841 - Seoul/KR

Abstract

Background

There have been reported that cancers and the cardiovascular system share common pathways, however, we do not fully understand the mechanism. Breast cancer also has been known to associate with cardiovascular disorders, including heart failure or cardiotoxicity related to chemotherapy. Therefore, we evaluated whether breast cancer, a chest wall disease, is associated with cardiac disorder.

Methods

Six hundred sixty eight patients who underwent sonography guided breast core biopsy from 2011 to 2013 were studied. All baseline 12-lead electrocardiogram (ECG) were assessed in 467 patients diagnosed with breast cancer (right, n = 225; left, n = 242) compared to 201 patients diagnosed with benign breast disease, as a control group. ECG parameter was also analyzed according to the position of malignancy. Twenty-four hours Holter ECGs were conducted in patients with abnormal ECG and/or symptom.

Results

All of patients were women and mean age of patients was 50.7 years. There were no difference in heart rate, QRS axis, bundle branch pattern, QRS duration, corrected QT interval, ST-segment change between two group. PR interval was significantly prolonged in the cancer group compared to benign group (155 ms vs. 149 ms, p = 0.001), however there was no significant difference in PR interval between patient with right breast cancer and those with left breast cancer (155ms vs 154ms, p = 0.768). In ECGs, ventricular premature complex (VPC) and atrial premature complex (APC) were documented only in breast cancer group (VPC, 0.64%; APC, 0.64%). Holter was conducted in 17 patients (cancer, n = 9, vs. benign disease, n = 8). Occasional APCs occurred more often in cancer group (66.7%, vs. 12.5%, p = 0.05).

Conclusions

This study showed that PR interval on ECGs was significantly prolonged and APCs was more prevalent in patients with breast cancer compared to those with benign breast disease before treatment. These findings suggest that breast cancer may be associated with the increase risk of arrhythmia. Therefore, clinicians should incorporate cardio-oncology practice from diagnosis to treatment to detect the cardiotoxicity of drugs and to observe possible cardiovascular or cardiometabolic benefits.

Clinical trial indentification

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.