387P - A single center retrospective paired study in west china hospital: cetuximab versus cisplatin concurrent with radiotherapy in nasopharyngeal carcinoma

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Head and Neck Cancers
Surgery and/or Radiotherapy of Cancer
Presenter Ping Li
Citation Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587
Authors X. Wu, H.M. Li, P. Li, L. Liu
  • Cancer Center, West China Hospital, Sichuan University, West China Hospital, Huaxi, Sichuan University, 610041 - Chengdu/CN

Abstract

Background

To evaluate the efficacy and toxicities of induction chemotherapy followed by cetuximab-based bioradiotherapy (BRT) or concurrent cisplatin-based chemoradiotherapy (CRT) in locally advanced nasopharyngeal carcinoma (NPC).

Methods

A total of 112 patients with previously untreated NPC, who received BRT and CRT with locally advanced nasopharyngeal carcinoma were matched into pairs, then enrolled into the study. All patients were given two cycles of induction chemotherapy (paclitaxel+ cisplatin+ fluorouracil) prior to following treatment regimen. Then they had either BRT (IMRT with weekly cetuximab) or CRT (IMRT with three weeks cisplatin). Patients were followed up with imaging examination and pharyngorhinoscopy. The treatment survival outcomes, toxicities and prognostic factors were evaluated.

Results

A total of 112 patients (56 in CRT and 56 in BRT) were enrolled. The 5-year overall survival (OS) were achieved as 79.3% in CRT and 79.5% in BRT arm respectively (p = 0.797), and the 5-year progresss free survival (PFS) were 73.5% and 74.6% respectively (p = 0.953). In analysis of toxicity, CRT arm had a greater percentage of grade III and IV toxicity of significant decreasing in WBC, PLT, hemoglobin and more severe vomiting, but BRT arm had more severe skin reactions and mucositis.

Conclusions

In terms of efficacy, BRT was equivalent to traditional CRT. In analysis of toxicity, CRT arm had a greater percentage of grade III and IV toxicity of significant decreasing in WBC, PLT, hemoglobin and more severe vomiting, but BRT arm had more severe skin reactions and mucositis. If patients cannot stand more severe toxicities caused by CRT, BRT could be an ideal alternative regimen.

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.