176P - Safety analysis of chemotherapy for colitis-associated colorectal cancer in Japan

Date 19 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 1
Topics Anticancer Agents
Colon and Rectal Cancer
Therapy
Biological Therapy
Presenter Kenta Nio
Citation Annals of Oncology (2015) 26 (suppl_9): 42-70. 10.1093/annonc/mdv523
Authors K. Nio1, D. Higashi2, H. Kumagai3, S. Arita3, T. Shirakawa4, K. Nakashima5, Y. Shibata6, M. Esaki7, T. Ueki8, M. Nakano3, H. Ariyama3, H. Kusaba3, M. Hirahashi9, Y. Oda9, T. Esaki10, K. Mitsugi11, K. Futami2, K. Akashi1, E. Baba12
  • 1Medicine And Biosystemic Science, Kyushu University Hospital, 812-8582 - Fukuoka/JP
  • 2Surgery, Fukuoka University Chikushi Hospital, Chikushino/JP
  • 3Medicine And Biosystemic Science, Kyushu University Hospital, Fukuoka/JP
  • 4Oncology, Miyazaki Prefectural Miyazaki Hospital, 880-8510 - Miyazaki/JP
  • 5Internal Medicine, University of Miyazaki Hospital, Miyazaki/JP
  • 6Medical Oncology, Wajiro Hospital, Fukuoka/JP
  • 7Medicine And Clinical Science, Kyushu University Hospital, Fukuoka/JP
  • 8Surgery And Oncology, Kyushu University Hospital, Fukuoka/JP
  • 9Anatomical Pathology, Kyushu University Hospital, Fukuoka/JP
  • 10Gastrointestinal And Medical Oncology, National Kyushu Cancer Center, 811-1395 - Fukuoka/JP
  • 11Oncology, Hamanomachi Hospital, Fukuoka/JP
  • 12Comprehensive Clinical Oncology, Kyushu University Hospital, 812-8582 - Fukuoka/JP

Abstract

Aim/Background

Inflammatory bowel diseases (IBD) often cause colorectal cancer. Efficacy and safety profile of chemotherapy (CT) for colitis-associated colorectal cancer (CAC) has not been well examined.

Methods

Patients with a CAC who were treated with CT between 2000 and 2014 were retrospectively examined.

Results

Twenty-nine patients (median age, 48 years; 23 males) were assessed. Palliative and adjuvant CT were performed in 13 and 16 patients, respectively. Eighteen patients had ulcerative colitis (UC), and 11 had Crohn's disease (CD). Three UC and 7 CD patients were in the active disease phase. Sixteen UC patients (89%) underwent proctocolectomy. Primary tumors were located in the rectum/anus (n = 16), the left colon (n = 9), or the right colon (n = 4). First-line palliative CT regimens were as follows: FOLFOX (fluorouracil (5-FU), leucovorin (LV), and oxaliplatin) (n = 6), FOLFOX + bevacizumab (BV) (n = 3), FOLFOX + cetuximab, FOLFIRI (5-FU, LV, and irinotecan) + BV and others (n = 2). Adjuvant CT regimens were S-1 (n = 7), UFT/LV (n = 3), FOLFOX (n = 2), XELOX (capecitabine and oxaliplatin) (n = 2) and others (n = 2). In palliative CT, the objective response rate was 15%, and median progression free survival and overall survival were 182 and 315 days, respectively. In adjuvant CT, 5-year relapse-free survival rate was 78%. Grade 3/4 adverse events (AE) were observed in 16 patients (55%). While 43% of active CD patients suffered G3/4 AE, no inactive CD patients had G3/4 AE. Dose-reduction was required in 11 patients (38%), 8 of which were due to hematological AE. CT was terminated because of AE in 7 cases, whereas only in 1 case caused by IBD.

Conclusions

While equivalent efficacy to the common colorectal cancer was achieved in adjuvant setting, modest efficacy in palliative setting was shown. CT was safely performed in CAC, however, consideration of the disease activity especially in CD is required.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.