516P - Outcomes of surgical treatment of long bones' diaphysis tumors

Date 20 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 2
Topics Bone Sarcomas
Surgical Oncology
Radiation Oncology
Presenter Bakhridil Sultonov
Citation Annals of Oncology (2015) 26 (suppl_9): 156-160. 10.1093/annonc/mdv535
Authors B.B. Sultonov1, K. Abdikarimov2, U. Islamov1, S. Urunbaev1, R. Davletov1
  • 1Musculosceletal Tumors, National Cancer Research Center of Uzbekistan, 100174 - Tashkent/UZ
  • 2Musculosceletal Tumors, National Cancer Research Center of Uzbekistan, Tashkent/UZ



To study the direct results of surgical treatment of patients with diaphyseal tumors of long bones.


Endoprosthetics for the replacement of post resectional defects of diaphysis of long bones was developed in surgical department of musculosceletal tumors of National Cancer Research Centre of the Health Ministry of the Republic of Uzbekistan (patent FAP 2012 0025 'Device for endoprosthetics of bone diaphysis'). Surgery using the prosthetics was performed in 16 patients with primary and metastatic tumors of long bones diaphysis. Men-8(50%), women-8 (50%), age of patients from 16 to 68. 12 patients were diagnosed primary tumors, in 4-metastatic affection (in one case- stomach and lungs cancer, in two case - breast cancer), all cases had solitary character. 12 patients had a diaphysis affection of thigh bone and in 4 cases humerus was affected as well. The length of affected bone was from 5 to 17 cm. Threat of pathological fracture was in 4 (25%) patients, fractures occurred in 12 (75%). All 16 patients segmental resection was performed with endoprosthetics. The length of resection was from 7 to 24 cm.


90 % of patients had not pain syndrome in post operative period. Patients were activated on the 2-5 days, that gives the possibility of independent service and continuation of special treatment. In distant period two complications were observed (12,5%). One patient after 12 months of endoprosthetics of thigh bone diaphysis loosening the upper legs of endoprosthetics occurred, in another patient after 14 months endoprosthetics of humerus, the loosening of lower legs of endoprosthetics occurred. Reendoprosthetics was performed in both cases. The functional condition by scale MSTS: after endoprosthetics of humerus diaphysis- 90 %, thigh bone -85%, anatomical-functional results by scale Enneking in 4 (25%) patients were marked as excellent, in 8 (50%) as good, and in 4 (25%) as satisfactory.


Thus, received results show efficacy of applying the developed device for endoprosthetics of bone diaphysis. Its usage for the replacement of formed post resectional defect of diaphysis allows to restore capability of functional condition of extremity and to get satisfactory anatomical-functional results.

Clinical trial identification


All authors have declared no conflicts of interest.