Intratumoral (IT) Injection of the TLR9 agonist tilsotolimod (IMO-2125) in combination with ipilimumab (ipi) triggers durable responses in PD-1 inh...

Date 20 October 2018
Event ESMO 2018 Congress
Session Poster Discussion session - Melanoma and other skin tumours
Topics Melanoma
Clinical Research
Immunotherapy
Presenter Adi Diab
Citation Annals of Oncology (2018) 29 (suppl_8): viii442-viii466. 10.1093/annonc/mdy289
Authors A. Diab1, C. Haymaker2, C. Bernatchez2, R.H.I. Andtbacka3, M. Shaheen4, D. Johnson5, J. Markowitz6, I. Puzanov7, R. Murthy8, D.H. Johnson1, M. James1, S. Chunduru9, J. Geib10, S. Swann11, S. Rahimian12, P. Hwu13
  • 1Melanoma, MD Anderson Cancer Center, 77030-4095 - Houston/US
  • 2Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 77030 - Houston/US
  • 3Surgical oncology, Huntsman Cancer Institute, 84112 - Salt Lake City/US
  • 4Medicine, University of Arizona Cancer Center North, Tucson/US
  • 5Medical Oncology, Vanderbilt University, Nashville/US
  • 6Medical Oncology, Moffitt Cancer Center, Tampa/US
  • 7Melanoma, Roswell Park Cancer Center, Buffalo/US
  • 8Interventional Radiology, MD Anderson Cancer Center, Houston/US
  • 9Translational Biology, Idera Pharmaceuticals, 19341 - Exton/US
  • 10Oncology Clinical Development, Idera Pharmaceuticals, 19341 - Exton/US
  • 11Biometrics, Idera Pharmaceuticals, Exton/US
  • 12Oncology, Idera Pharmaceuticals, 19341 - Exton/US
  • 13Melanoma, MD Anderson Cancer Center, 77030 - Houston/US

Abstract

Background

Subsequent treatment with ipi offers 10-13% ORR (Bowyer 2016, Long 2016) in aPD1 refractory MM. Tilsotolimod, a synthetic TLR9 agonist oligonucleotide, acts on macrophages and dendritic cells to alter the tumor microenvironment. Local drug-induced type 1 interferon response results in increased antigen presentation and downstream T cell activation and proliferation in injected and non-injected lesions (Haymaker, SITC 2017).

Methods

The study will enroll up to 60 pts with rMM to receive IT (with/without IG) tilsotolimod (scheduled weeks 1,2,3,5,8,11,17, 23 and 29); ipi is given per the product label starting at week 2. Pts with M1c disease, mucosal melanoma and BRAF mutations were included. The primary endpoint is RECIST1.1 objective response rate (ORR); other endpoints are safety and tolerability and disease control rate (DCR). Immune analyses of T-cell repertoire diversity evaluated by high-throughput CDR3 sequencing. Phase 2 accrual is ongoing.

Results

As of 9 Apr 2018, 26 pts have been treated with tilsotolimod 8mg+ ipi, including 5 pts who received IG injections to deep visceral lesions or lymph nodes. Median age: 65.8 (range 39-91 yrs); 11 IVM1c. 6 pts had irAEs [hypophysitis (2), hepatitis (2), adrenal insufficiency (1), Guillain-Barre syndrome (1), colitis (1), enterocolitis (1)], which responded to standard measures. Injection-related toxicities were grade 1-2 transient fever and flu like symptoms lasting <48 hours. Major expanding T-cell clones are found to be shared in responding local and distant lesions indicating that reactivation is to a shared antigen in responding patients. As of 9 May 2018, 21 pts were assessed for response: 38% ORR and 71% DCR (2 CR, 6 PR, 7 SD). 6 of 8 responses are ongoing including 1 CR > 23 mo. 10 pts had BRAF mutations (1 CR, 3 PR, and 4 SD).

Conclusions

IT tilsotolimod 8mg+ ipi is well tolerated and shows substantial clinical benefit and durable responses. The ORR of 38% compares favorably to ipi in this challenging population, leading to an ongoing global randomized Phase 3 study of tilsotolimod 8mg+ipi vs. ipi in aPD-1 rMM.

Clinical trial identification

NCT02644967.

Legal entity responsible for the study

Idera Pharmaceuticals.

Funding

Idera Pharmaceuticals.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.