1554P - Impact of cancer on the quality of life of Tunisian pediatric patients

Date 22 October 2018
Event ESMO 2018 Congress
Session Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Topics Psychosocial Aspects of Cancer
Presenter Feryel Letaief-Ksontini
Citation Annals of Oncology (2018) 29 (suppl_8): viii557-viii561. 10.1093/annonc/mdy296
Authors F. Letaief-Ksontini1, T. Dorra2, S. Masmoudi3, K. Meddeb4, A. Mokrani4, Y. Yahyaoui4, A. Gabsi1, M. Ayadi4, N. Chraiet4, H. Raies5, A. Mezlini4
  • 1Medecine, Salah Azaiez Institute, 1006 - Tunis/TN
  • 2Medecine, Institut Salah Azaïz, 1006 - Tunis/TN
  • 3Medical Oncology, Salah Azaiez Institute of Cancer, 1006 - Tunis/TN
  • 4Medical Oncology, Salah Azaiez Institute, 1006 - Tunis/TN
  • 5Medical Oncology, Salah Azaiez Cancer Institute, 1006 - Tunis/TN



The PedsQL (Pediatric Quality of Life Inventory) is an instrument which measures health-related quality of life (HRQOL) in children and young adults. The PedsQL 4.0 Generic Core Scales (GCS) are child self-report and parent proxy-report scales developed to be integrated with the PedsQL disease specific modules. The PedsQL 3.0 Cancer Module (CM) was designed to measure pediatric cancer specific HRQOL. The aim of this study was to evaluate the impact of their disease and its treatments on their physical, mental and social health.


This prospective study included 26 patients newly diagnosed and relapsed, on-treatment, from the pediatric ward of Salah Azaiez Institute. Their ages were 5 to 25 years-old. The 23-item PedsQL 4.0 GCS encompass 4 scales: physical, emotional, social, and school functioning. The cancer module scales has 27 items which encompasses 8 scales: pain and hurt, nausea, procedural anxiety, treatment anxiety, worry, cognitive problems, perceived physical appearance and communication. The format instructions, response scale and scoring method are identical for GCS and CM. The scores are between [0-100]. We translated the English version of the GCS and the CM into arabic.


All the children completed their self-report .The mean age was 15.5 years-old.53.8% were boys.27.07% of patients had brain tumors, 19.2% osteosarcoma,19.2% Ewing sarcoma and 11.5%Undifferentiated nasopharyngeal cancer (UCNT). Twenty patients were newly diagnosed. Eight cases had metastatic disease.The child total GCS mean was 60.86 physical score mean 64.06 and social score mean 67.5. For the child total CM score mean, it was 61.53 ; pain score mean 75, nausea score mean 50 which is the lowest and the worry score mean 62.49 . We found that the nausea score is higher for children with intensive chemotherapy (p value=0.026). The parent proxy total GCS mean was lower than the child`s score 58.69 as well as the total CM parent score mean which was 60.17. We didn`t find significant difference between the age of the patient, staging of his disease and the pedsQL scores.


The HRQL of children is adversely affected as a result of the uncontrolled symptoms from cancer treatment. In Tunisia, we should work more to improve the pediatric HRQL.

Clinical trial identification

Legal entity responsible for the study

Salah Azaiez Intitute.


Has not received any funding.

Editorial Acknowledgement


All authors have declared no conflicts of interest.