Cognitive functions, coping strategies and psychological distress in patients with resected non-advanced cancer receiving chemotherapy: NEOcoping s...

Date 22 October 2018
Event ESMO 2018 Congress
Session Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Topics Psychosocial Aspects of Cancer
Presenter Oliver Higuera Gomez
Citation Annals of Oncology (2018) 29 (suppl_8): viii557-viii561. 10.1093/annonc/mdy296
Authors O. Higuera Gomez1, C. Calderón2, I. Ghanem1, A. Carmona-Bayonas3, C. Jara4, R. Hernández5, B. Castelo1, M.M. Muñoz6, C. Beato7, S. García8, E. Martínez9, M. Mut10, A. Ramchandani Vaswani11, M. Mangas12, O. Donnay13, M.T. García-García14, M.C. Soriano6, R. Carrión15, C. Iglesias Gomez16, P. Jimenez Fonseca16
  • 1Medical Oncology, Hospital Universitario La Paz, 28046 - Madrid/ES
  • 2Clinical Psychology And Psychobiology, University of Barcelona, Barcelona/ES
  • 3Medical Oncology, Hospital Universitario Morales Meseguer, Murcia/ES
  • 4Medical Oncology, Hospital Universitario Fundación Alcorcón, Madrid/ES
  • 5Medical Oncology, Hospital Universitario de Canarias, Tenerife/ES
  • 6Medical Oncology, Hospital Virgen de La Luz, Cuenca/ES
  • 7Medical Oncology, . Hospital Universitario Virgen de la Macarena, Sevilla/ES
  • 8Medical Oncology, Hospital Universitario de la Santa Cruz i Sant Pablo, Barcelona/ES
  • 9Medical Oncology, Hospital Universitario Marqués de Valdecilla, Santander/ES
  • 10Medical Oncology, Hospital Universitario Son Espases, Mallorca/ES
  • 11Medical Oncology, Hospital Universitario Insular de Gran Canaria, 35016 - Las Palmas/ES
  • 12Medical Oncology, Hospital Galdakao-Usansolo, Galdakao-Usansolo/ES
  • 13Medical Oncology, Hospital Universitario de La Princesa, 28006 - Madrid/ES
  • 14Medical Oncology, Hospital Universitario Santa Lucia, 30202 - Cartagena/ES
  • 15Medical Oncology, Hospital Universitario del Sureste, Madrid/ES
  • 16Medical Oncology, Hospital Universitario Central de Asturias, 33006 - Oviedo/ES



The loss of cognitive functions is a symptom that impairs the quality of life .The aim of this study is to analyze cognitive functioning in cancer patients who initiate chemotherapy and to study the relationship between coping strategies and psychological distress.


NEOcoping is a national, multicenter, cross-sectional, prospective study of the Continuous Care Group of the Spanish Society of Medical Oncology conducted between January 2016 and January 2018 in 14 Medical Oncology departments in Spain. The population consisted of patients with histologically confirmed, non-advanced cancer treated with surgery for which international clinical guidelines considered that adjuvant treatment could be an option.The information was collected and updated by medical oncologists through a web-based platform ( Questionnaires for doctors and patients were filled out before starting adjuvant chemotherapy and at the end of the treatment. The applied tests were: Mini-Mental Adjustment to Cancer (Mini-MAC), EORTC core quality of life questionnaire (EORTC QLQ-C30, cognitive function scale), and Brief Symptom Inventory (BSI-18).


Seven hundred and ninety-five patients were recruited. The median age was 58 years and 60% were women. Most were married or partnered (77%) and had a primary level of education (56%). The most common employment status was retired (59%). The primary tumor localization was mainly colorectal (41%) and breast (34%) and the stage was I-II (56%) or III (44%).The results indicate that patients who perceived their physical condition or chemotherapy interfered with their cognitive functions had more anxious coping strategies characterized by constant preoccupation with the type of health, fear of cancer recurrence and this led to a search for frequent reaffirmation (p = 0.008). The cognitive function problems were negatively related with somatization (p < 0.001), depression (p < 0.001) and anxiety (p < 0.001).


The perception of impaired cognitive abilities and uncertainty about the prognosis of cancer can make it difficult for patients to adapt to their situation, deteriorate quality of life and increase emotional distress.

Clinical trial identification

Legal entity responsible for the study

Continuous Care Group of the Spanish Society of Medical Oncology (SEOM).


Sociedad Española de Oncología Médica (SEOM).

Editorial Acknowledgement


All authors have declared no conflicts of interest.