1453P - Tobacco exposure and adverse pathological features in oral cancer : does age impact survival ?

Date 10 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Cancers in Adolescents and Young Adults (AYA)
Aetiology, epidemiology, screening and prevention
Head and Neck Cancers
Basic Scientific Principles
Presenter Vijay Srinivasalu
Citation Annals of Oncology (2017) 28 (suppl_5): v511-v520. 10.1093/annonc/mdx385
Authors V. Srinivasalu1, N. Subramaniam2, D. Balasubramaniam2, N. Kumar3, S. Murthy2, A. Susan1, A. Philip1, K. Thankappan2, S. Iyer2, P. Keechilat1
  • 1Department Of Medical Oncology, Amrita institute of medical sciences, 682041 - KOCHI/IN
  • 2Department Of Head And Neck Oncology, Amrita institute of medical sciences, 682041 - KOCHI/IN
  • 3Gcsrt Program, Harvard medical school, cambridge/GB



The role of tobacco in oral cancer is well established, however there is a wide variation in the incidence of tobacco - related oral cancer in the literature, ranging between 70-90%. Our data shows that only half of the patients with oral cancer have any history of tobacco exposure (smoking, chewing or others). Younger patients with oral cancer (


From a prospectively maintained database of patients treated for oral cancer in our institution, we extracted details for 643 patients of oral cavity squamous cell carcinoma. We divided these patients into four groups, younger patients (


The percentage of those with tobacco exposure was comparable in both age groups. Tobacco exposure correlated with tumour thickness (p = 0.001), perineural invasion (p = 0.002), lymphovascular invasion (p = 0.004) and local recurrence (p = 0.006) in the younger patients but not in the older patients. In younger patients, those with tobacco exposure also had a positive trend for poorer differentiation (p = 0.07) and extranodal extension (p = 0.06). Patients


Younger patients with exposure to tobacco have worse clinical outcome, possibly as a result of adverse pathological features like perineural invasion and lymphovascular invasion. Whether this relationship is due to an underlying immune mechanism requires further study. Younger tobacco users with oral cancer are more likely to have a poor prognosis.

Clinical trial identification

This is not a clinical trial

Legal entity responsible for the study

Amrita Institute of Medical Sciences, Kochi, India




All authors have declared no conflicts of interest.