983P - Investigation of the clinicopathological features of vulva cancer: a retrospective survey of the JGOG Net Work study.

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Vulvar and Vaginal Cancers
Gynaecologic Malignancies
Presenter Shin Nishio
Citation Annals of Oncology (2017) 28 (suppl_5): v330-v354. 10.1093/annonc/mdx372
Authors S. Nishio1, T. Shibata2, S. Yamaguchi3, H. Kanao4, A. Kojima5, M. Takekuma6, A. Tozawa7, H. Tokunaga8, E. Miyagi9, H. Kato10, K. Kurihara11, T. Yanase12, K. Ushijima1, M. Mikami13, T. Sugiyama14
  • 1Obstetrics And Gynecology, Kurume University, 830-0011 - Kurume/JP
  • 2Molecular Life Sciences, Tokai University, Isehara/JP
  • 3Gynecology, Hyogo Cancer Center, Akashi/JP
  • 4Gynecology, Cancer Institute Hospital, Tokyo/JP
  • 5Obstetrics And Gynecology, Iwate Medical University, Morioka/JP
  • 6Gynecologic Oncology, Shizuoka Cancer Center, Shizuoka/JP
  • 7Obstetrics And Gynecology, St. Marianna University, Kawasaki/JP
  • 8Obstetrics And Gynecology, Tohoku University Hospital, Sendai/JP
  • 9Obstetrics And Gynecology, Yokohama City University Hospital, Yokohama/JP
  • 10Gynecology, Kanagawa Cancer Center, Yokohama/JP
  • 11Gynecology, Saitama Cancer Center, Saitama/JP
  • 12Gynecology, Niigata Cancer Center Hospital, Niigata/JP
  • 13Obstetrics And Gynecology, Tokai Univeresity Hospital, Isehara/JP
  • 14Department Of Obstetrics And Gynecology, Iwate Medical University School of Medicine, 020-8505 - Morioka/JP



Vulvar cancer is a rare malignancy in women. During the past 30 years, large surveys of vulva cancer have not been performed in Japan. We therefore conducted a multicenter study to clarify the clinicopathological features of vulva cancer in Japan (UMIN000017080).


In this multicenter retrospective cohort study, the clinical data of patients with vulva cancer were surveyed. The medical records of patients with vulvar cancer patients treated between 2001 and 2010 were retrospectively reviewed after obtaining approval from the Institutional Review Board of each institution. Survival analysis was performed using Kaplan-Meier curves. The effects of the clinical factors on OS were investigated using a Cox regression model.


A total of 1082 patients treated in 108 centers were studied. The median age was 72 years (range, 20 to 96). The disease stage was stage I in 415 patients (38.3%), stage II in 249 (23%), stage III in 255 (23.6%), and stage IV in 163 (15.1%) (FIGO 2009). The diagnosis was squamous cell carcinoma in 779 patients (72%), Paget’s disease in 158 (14.6%), adenocarcinoma in 63 (5.8%), and others in 82 (7.6%). Positive lymph nodes were found in 237 patients (21.9%). The median tumor diameter was 35 mm (range, 1 to 180). The 5-year overall survival was 86% in stage I, 74.7% in stage II, 48.2% in stage III, and 39.3% in stage IV (P 


Treatment outcomes in Japanese patients with vulvar cancer were similar to those reported previously. However, squamous-cell carcinoma, adenocarcinoma, positive lymph nodes, and bulky tumors were associated with poor outcomes. Multidisciplinary treatment might be required in patients with these characteristics.

Clinical trial identification

Registry Name: UMIN Clinical Trials Registry Registration Number: UMIN000017080

Legal entity responsible for the study





All authors have declared no conflicts of interest.