708P - Epidemiological study of histologically proven advanced hepatocholangiocarcinoma : an AGEO multicenter retrospective study

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Hepatobiliary Cancers
Aetiology, epidemiology, screening and prevention
Gastrointestinal Cancers
Basic Scientific Principles
Presenter Yann Touchefeu
Citation Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369
Authors Y. Touchefeu1, C. Prieux-Klotz2, D. Tougeron3, T. Lecomte4, M. Caulet4, T. Matysiak Budnik1, V. Hautefeuille5, M. Tiako-Meyo6, A. Zaanan7, M. Salimon1
  • 1Imad, Department Of Gastroenterology, Nantes University Hospital, 44093 - Nantes/FR
  • 2Department Of Gastroenterology, Cochin University Hospital, 75014 - Paris/FR
  • 3Department Of Gastroenterology, CHU Poitiers, Jean Bernard Hôpital, 86021 - Poitiers/FR
  • 4Department Of Gastroenterology, CHU de Tours, Hôpital Trousseau, 37170 - Chambray-lès-Tours/FR
  • 5Department Of Gastroenterology, CHU Amiens-Picardie Site Nord, 80054 - Amiens/FR
  • 6Department Of Gastroenterology, Hôpital Européen Georges Pomipdou, 75015 - Paris/FR
  • 7Department Of Gastroenterology, Hopital European Georges Pompidou, 75015 - Paris/FR



Hepatocholangiocarcinoma (cHCC-ICC) is a rare primary hepatic tumor combining the features of cholangiocarcinoma and hepatocellular carcinoma. Few data about the epidemiology of cHCC-ICC have been reported, mainly from surgical series in Asian and American populations. The aim of this study was to evaluate epidemiological features and overall survival (OS) of histologically proven advanced cHCC-ICC patients.


Data from patients treated for histologically proven cHCC-ICC in six French university hospitals between 2008 and February 2017, were retrospectively collected. The main clinical, biological, treatment and follow up data were reported. Statistical analysis was performed using Graph Pad Prism 6.


Thirty patients were included (76.6% of men, median age 64 years [extreme 37-88]). Cirrhosis was associated in 33.3% of cases (Child-Pugh score A: 70%). Positive serology for hepatitis B virus and C was found in respectively, 5 (16.6%) and 2 (6.6%) patients; with 1 co-infection. Chronic alcoholism was noted in 33.3%, diabetes and obesity were both present in 26.6% of cases. Alpha-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonnic antigen serum levels were above normal in respectively 39% (median = 5.3 μg/L [2 – 21 479]), 50% (median = 21.8 IU/mL [4.5-20 000]) and 14% (median = 2.4 µg/L [2-88]) of cases. Six patients (20%) were initially treated by surgical resection. At the diagnosis of advanced disease, 66.6% of patients had multifocal hepatic lesions, 50% distant metastases (bone (23.3%), lung (20%), peritoneal metastases (13.3%)). Twenty-seven patients (90%) received first line of systemic treatment. Twenty-four patients were treated by chemotherapy: Gemcitabine (Gem) alone (n = 1), Gem+oxaliplatin (Gemox) (n = 12), Gemox + bevacizumab (n = 9), Gem+cisplatin (n = 2). Two patients received chemoembolization, 1 patient received sorafenib. Twenty-one (70%) and 4 (13.3%) patients had a second and third line of treatment, respectively. Median OS was 14.5 months.


Advanced cHCC-ICC appear to be aggressive tumors with a poor prognosis. Cirrhosis was associated in one third of cases. Systemic treatments are not standardized and must be evaluated in a dedicated study.

Clinical trial identification

Legal entity responsible for the study

Dr. Yann Touchefeu




All authors have declared no conflicts of interest.