223P - Early characteristics of breast neoplasms on contrast-enhanced ultrasonography and its clinical value

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Breast Cancer
Staging procedures (clinical staging)
Basic Principles in the Management and Treatment (of cancer)
Presenter SI Qin
Citation Annals of Oncology (2017) 28 (suppl_5): v68-v73. 10.1093/annonc/mdx364
Authors S. Qin, Z.W. Jie
  • Ultrasound Medicine, Nanjing Jingdu hospital, 210002 - Nanjing/CN



To investigate the characteristics of breast neoplasms on contrast-enhanced ultrasonography and its clinical value.


225 female patients with breast masses unable to be diagnosed by conventional ultrasonography were examined with contrast-enhanced ultrasonography (CEUS). Their ages range were 12 to 85 years, the mean age was (45.8±17.6) years. 225 cases were investigated. For cases of multiple lesions, performed which was the highest classification level of BI-RADS; for the lesions of the same level, performed the largest lesion. The characteristics of these masses on CEUS were analyzed and compared with the results of pathology examination. The contrast agent(UCA) was SonoVue (Bracco, Italy).


91 cases were malignant and 134 cases were benign. The 91 malignacies displayed: irregular shapes were 80.2%(73/91), tortuous, massive or penetrating vessels were 86.8% (79/91), heterogeneous distribution of contrast enhancement were 83.5% (76/91), perfusion defect of contrast signals were 89.0% (81/91), local retention of contrast signals were 93.4% (85/91), rapidly entering and exporting from the lesions were 65.9% (60/91). Significant differences of above CEUS characteristics were found between the benign and malignant breast lesions (P 


The typical features of breast cancers on CEUS were irregular shapes, tortuous, massive or penetrating vessels, heterogeneous distribution of contrast enhancement, with perfusion defect or local retention of contrast signals, rapidly entering and exporting from the lesions, enlarged maximum diameter of the lesions on CEUS compared to pre-contrast. It is valuable for CEUS in the diagnosis and differential diagnosis of breast neoplasms clinically.

Clinical trial identification

From 2011 to 2015

Legal entity responsible for the study

The Center of Interventional Ultrasound Diagnosis in Nanjing Region




All authors have declared no conflicts of interest.