601P - Colon and rectal cancer incidence are rising among young Europeans: Results from the cancer registry of Crete.

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Aetiology, epidemiology, screening and prevention
Colon and Rectal Cancer
Gastrointestinal Cancers
Cancers in Adolescents and Young Adults (AYA)
Basic Scientific Principles
Presenter Dimitra Sifaki-Pistolla
Citation Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393
Authors D. Sifaki-Pistolla1, E. Saloustros2, G. Pitsoulis3, L. Vamvakas4, D. Mavroudis4, V. Georgoulias5, C. Lionis1
  • 1Social And Family Medicine Clinic, University of Crete, School of Medicine, 71110 - Heraklion/GR
  • 2Oncology Unit, General hospital of Heraklion 'Venizelio', 714 09 - Heraklion/GR
  • 3Region Of Crete, Regional council, 71402 - Heraklion/GR
  • 4Medical Oncology, University hospital of Heraklion, 71110 - Heraklion/GR
  • 5Medical Oncology, University of Crete, School of Medicine, 71110 - Heraklion/GR



Colorectal cancer (CRC) incidence is declining rapidly overall in most European countries. Curiously, in the United States, a worrisome increase in incidence has recently been reported among young adults. We report the first study on this specific age group in the European population.


This retrospective study was conducted in Crete, Greece using data on malignant neoplasms of the colon (ICD-10: C18), rectosigmoid junction and rectum (ICD-10: C19-20). Data were obtained from the database of the regional Cancer Registry of Crete () and coded according to the international classification system for Oncology (ICD10-O-2). Information on patient’s demographic profile, personal and family medical history and lifestyle factors (smoking habits, alcohol consumption) were also available. The analysis was performed in STATA, while all tests were at a = 0.05.


The mean age-specific incidence rates (ASpIR) of CRC patients


We confirmed in European population an increased incidence of CRC under the age of 50 and a worrisome prediction for the near future. Since mortality in young adults with CRC is high, efforts to promote research and awareness among patients and physicians about the unique characteristics of early-onset CRC are critical.

Clinical trial identification

Legal entity responsible for the study

Cancer registry of Crete




All authors have declared no conflicts of interest.