970P - Triweekly versus weekly cisplatin concurrent with radiotherapy in locally advanced nasopharyngeal carcinoma

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Anticancer agents
Head and Neck Cancers
Surgical oncology
Therapy
Biological therapy
Radiation oncology
Presenter Mei Lan
Citation Annals of Oncology (2016) 27 (6): 328-350. 10.1093/annonc/mdw376
Authors M. Lan1, S. Wu1, F. Han1, M. Deng1, C. Chen1, Y. Huang1, Z. Duan2, J. Liao1, L. Tian3, L. Zheng3, T. Lu1
  • 1Radiation Oncology, Cancer Centre Sun Yat-Sen University, 510060 - Guangzhou/CN
  • 2Radiation Diagnosis And Interventional Center, General Hospital of Chengdu Military Region, 610213 - Chengdu/CN
  • 3Imaging Diagnosis And Interventional Center, Cancer Centre Sun Yat-Sen University, 510060 - Guangzhou/CN

Abstract

Background

Comparative studies on triweekly and weekly cisplatin in locally advanced nasopharyngeal carcinoma (NPC) were all based on small sample size, and no definitive conclusion has been reached. The aim of this study was to compare the outcomes of concurrent chemoradiotherapy (CCRT) using two different schedules of cisplatin in patients with locally advanced NPC.

Methods

From January 2007 to December 2011, 1582 patients with stage II-IVb NPC, treated with CCRT alone were reviewed. Eight hundred and two patients received triweekly cisplatin (80-100 mg/m2 every three weeks, two to three cycles) and 780 patients received weekly cisplatin (30-40 mg/m2 every week, over five cycles). Clinical characteristics and treatment factors were well balanced in two groups. Overall survival (OS), disease–free survival (DFS), locoregional recurrence–free survival (LRRFS), distant metastasis-free survival (DMFS) and acute toxicity profiles were calculated.

Results

Median follow-up time was 64 months (range, 4–194 months). For the entire cohort, the distant metastasis risk was decreased by 30% in the triweekly group than weekly group (hazard ratio [HR] = 0.70; 95% confidence interval [CI]: 0.49-0.99). Subgroup analysis revealed that triweekly cisplatin could further improve patients' 5-year DMFS (92.6% vs. 85.8%, P 

Conclusions

Triweekly cisplatin treatment is more effective than weekly cisplatin regimen in reducing distant metastases in patients with locally advanced NPC, especially for those with N3 or stage IV diseases and who were treated with IMRT.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

This research was supported by Grants from the Natural Science Foundation of China (81402244).

Disclosure

All authors have declared no conflicts of interest.