88P - Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients

Date 10 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Translational Research
Basic Principles in the Management and Treatment (of cancer)
Presenter Aviad Zick
Citation Annals of Oncology (2016) 27 (6): 15-42. 10.1093/annonc/mdw363
Authors A. Zick1, T. Peretz1, M. Lotem2, A. Hubert2, D. Katz2, M. Temper2, Y. Rottenberg2, B. Uziely2, H. Nechushtan2, A. Meirovitz2, A. Sonnenblick2, E. Sapir2, D. Edelman2, Y. Goldberg2, A. Lossos3, S. Rosenberg3, I. Fried4, R. Finklstein5, E. Pikarsky5, H. Goldshmidt5
  • 1Oncology, Hadassah Ein Kerem, 91120 - Jerusalem/IL
  • 2Oncology, Hadassah Ein Kerem, Jerusalem/IL
  • 3Neuro-oncology, Hadassah Ein Kerem, Jerusalem/IL
  • 4Pediatrics, Hadassah Ein Kerem, Jerusalem/IL
  • 5Pathology, Hadassah Ein Kerem, Jerusalem/IL

Abstract

Background

Molecular portraits of numerous tumors have flooded oncologists with vast amounts of data. In parallel, effective inhibitors of central pathways have shown great clinical benefit. Together, this promises potential clinical benefit to otherwise end-stage cancer patients.

Methods

Here, we report a clinical service offering mutation detection of archived samples using the ion Ampliseq™ cancer panel coupled with clinical consultation. A multidisciplinary think tank consisting of cancer-biologists, genetic counselors, oncologists, and pathologists discussed 67 patient cases, taking into account the identified mutations, the case history and relevant literature.

Results

The team generated a treatment plan, targeting specific mutations, for 41 out of 64 cases. Three patients died before results were available. For 32 patients, the treating oncologists chose not to include the panel recommendation in the treatment plan for various reasons. Nine patients were treated as recommended by the panel, five with clinical benefit and four with disease progression.

Conclusions

This study suggests that routine use of massive parallel tumor sequencing is feasible and can judiciously affect treatment decisions when coupled with multidisciplinary team-based decision making. Administration of personally based therapies at an earlier stage of therapy, expansion of genetic alterations examined and increased availability of biological therapies may lead to further improvement in the clinical outcome of patients.

Clinical trial identification

Legal entity responsible for the study

Hadassah Medical Organization

Funding

Hadassah Medical Center

Disclosure

All authors have declared no conflicts of interest.