343P - The role of ABO blood groups in glial neoplasia

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Central Nervous System Malignancies
Presenter Ali Alkan
Citation Annals of Oncology (2016) 27 (6): 103-113. 10.1093/annonc/mdw367
Authors A. Alkan1, G. Yazıcı2, M. Cengiz2, İ. Çelik3, A. Kars3, F. Zorlu2
  • 1Medical Oncology, Ankara University Medical School-Cebeci Hastaneleri Tıbbi Onkoloji, 06590 - Ankara/TR
  • 2Radiation Oncology, Hacettepe University Faculty of Medicine, 06590 - Ankara/TR
  • 3Medical Oncology, Hacettepe University Faculty of Medicine, 06590 - Ankara/TR

Abstract

Background

There are numerous diseases that are claimed to have a correlation with ABO blood groups. The association with malignancy, especially with exocrine pancreas malignancy, has been documented. Analysis on distribution of blood groups in primary brain tumors and clinical value has revealed conflicting results. Here we aimed to evaluate the association between blood groups and glial neoplasia.

Methods

Patients admitted between 2000–2013 and had a diagnosis of glial neoplasia were evaluated. Documented blood groups were analyzed and compared with the National blood group data obtained from Turkish Red Crescent Society. The prognostic significance of ABO blood groups was analyzed within glioblastoma multiforme (GBM), anaplastic astrocytoma and grade 1-2 astrocytoma.

Results

759 patients with a diagnosis of glial neoplasia were evaluated. Distribution of ABO blood groups in the different grades of glial neoplasia was similar with the national blood group frequencies. There was no statistically significant difference between all grades of glial neoplasia and healthy control patients. Median overall survival (mOS) of GBM patients are 12.9, 13.4, 5.7, 12.8 months in A, B, AB, and O blood groups, respectively (p = 0.46). mOS of anaplastic astrocytoma patients are 24.4, 47.2, 37.8, 29.2, 25.7 months, respectively (p = 0.96). mOS in grade1-2 astrocytoma in different blood groups are similar (p = 0.80).

Conclusions

In our small patient group, when compared with general population, there seems to be no association between frequencies of ABO blood groups and glial neoplasia. The ABO blood groups have no prognostic impact on glial neoplasia.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.