1332P - The hormonal status of girls from Kyiv and evacuees from Pripyat

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Aetiology, epidemiology, screening and prevention
Basic Scientific Principles
Presenter Dmytro Burlaka
Citation Annals of Oncology (2016) 27 (6): 462-468. 10.1093/annonc/mdw385
Authors D. Burlaka1, N. Hutnyk2
  • 1Department Of Biotechnical Problems Of Diagnostics, Institute of Cryobiology and Cryomedicine National Academy of Sciences of Ukraine, 03028 - Kyiv/UA
  • 2Department Of Mechanisms Of Metastasis, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv/UA

Abstract

Background

A study was conducted of serum hormone levels among girls from Pripyat and Kyiv 5 years after the Chornobyl accident. Variations of hormonal status in pre- and pubertal girls evacuated from the town Pripyat and girls from the city of Kyiv were this revealed.

Methods

We investigated the hormones in the blood serum of 749 girls from Pripyat (504) and Kyiv (245). Age girl was 10-15 years. The study was conducted in Kyiv with the support of Ukrainian-French medical center "Children of Chornobyl". Radioimmunoassay was used to determine the the blood serum hormones: testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), cortisol (F), triiodothyronine (T3) thyroxine (T4), progesterone (P4), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH).

Results

In surveys of girls from Pripyat we established 7 statistically significant diferences in 7 hormone levels: T, FSH, LH, E2, PRL, F, T4. Serum of girls from Pripyat compared with serum of girls from Kyiv had levels of T, FSH, LH higher than in controls (p 

Conclusions

Revealed abnormalities in the hormonal status of the girls surveyed, obviously, is the result of functional disorders of the endocrine system. Such dysfunction does not give explicit symptoms and thus remain unnoticed by the doctor. The girls identified with hormonal disorders, obviously, are a group at high risk for the occurrence of tumors caused by hormones.

Clinical trial identification

Legal entity responsible for the study

Ukrainian-French medical center "Children of Chornobyl", NAS of Ukraine

Funding

Prominvestbank, bank"LIS"

Disclosure

All authors have declared no conflicts of interest.