538P - The genomic complexity of metastatic colorectal tumors by age, gender, race, and location of primary tumor using next-generation sequencing

Date 08 October 2016
Event ESMO 2016 Congress
Session Poster Display
Topics Colon and Rectal Cancer
Presenter Jun Gong
Citation Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370
Authors J. Gong, M. Sy, M. Fakih
  • Medical Oncology And Experimental Therapuetics, City of Hope, 91010 - Duarte/US

Abstract

Background

Recent molecular profiling has identified a growing number of mutations that are considered targetable in metastatic colorectal cancer (mCRC). We aimed to explore the genomic complexity of metastatic colorectal tumors by patient factors such as age, gender, race, and site of primary tumor using next-generation sequencing (NGS).

Methods

We conducted a retrospective study based on comprehensive genomic profiling of tumors from patients (pts) with predominantly mCRC at our single institution using NGS via FoundationOne. All classes of genomic alterations were identified and their frequencies analyzed according to age (

Results

Among 210 tumors that underwent FoundationOne analysis, frequencies of the following mutations in pts

Conclusions

There is increased genomic complexity observed in several molecular alterations of potential significance in mCRC based on age, gender, race, and site of primary tumor. These findings inform ongoing studies of larger size and prospective design that aim to analyze molecular signatures in metastatic colorectal tumors and their significance to prognosis and therapeutic targeting.

Clinical trial identification

Legal entity responsible for the study

City of Hope

Funding

City of Hope

Disclosure

All authors have declared no conflicts of interest.