298P - Survival patterns of T2 & T3 breast cancer according to different modalities of treatment in the United States

Date 10 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Breast Cancer, Locally Advanced
Presenter Mohamed Ramadan
Citation Annals of Oncology (2016) 27 (6): 68-99. 10.1093/annonc/mdw365
Authors M. Ramadan, A. Meshref, M. Mousa
  • Faculty Of Pharmacy, Suez Canal University, 42524 - Ismailia/EG

Abstract

Background

The study aim to detect five years relative survival rate of T2 & 3 stage of breast cancer with radiotherapy (RT) and surgical treatment

Methods

The patient data was obtained from SEER database using all 18 SEER registries. We included patient who diagnosed with breast cancer between 1998 & 2007 with T2 & 3 stage according to breast-Adjusted American Joint Committee on Cancer 6th edition for 1998. Five years relative survival rates of patients with different modalities of treatment calculated and compared among groups of patients categorized by T stage.

Results

117498 patient included depending on selection criteria from SEER database. The result showed that there is significant difference (P value >0.001) in five years relative survival rate in T2 stage between patient who not received neither RT nor surgery 53.6% (95%CI:50.5-56.6) comparing with patient who received RT only 86.4% (95%CI:79.8-90.9). Also there is significant difference (P value =0.029) in five years relative survival rate in T3 stage between patient who not received neither RT nor surgery 46.5% (95%CI:41.6-51.2) comparing with patient who received RT only 55.9% (95%CI:44.7-65.6). Also there is significant difference (P value >0.001) in five years relative survival rate in T2 stage between patient who received surgical intervention only 86.6% (95%CI:86.2-87) comparing with patient who received RT combined with surgical intervention 90.5% (95%CI:90.1-90.8). Also there is significant difference (P value >0.001) in five years relative survival rate in T3 stage between patient who received surgical intervention only 70.9% (95%CI:69.6-72.1) comparing with patient who received RT combined with surgical intervention 82.1% (95%CI:81.1-83).

Conclusions

RT has high five years relative survival rate with T2 &3 stage in breast cancer patient. Also RT combined with surgical intervention has better five years relative survival rate with T2&3 stage of breast cancer than surgical intervention only.

Clinical trial identification

Legal entity responsible for the study

Mohammed Ramadan

Funding

Mohammed Ramadan

Disclosure

All authors have declared no conflicts of interest.