267P - Survival pattern of negative lymph node non-metastatic breast cancer females in the United States with radiotherapy treatment according to estrogen...

Date 10 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Surgical Oncology
Breast Cancer
Therapy
Radiation Oncology
Presenter Ahmed Meshref
Citation Annals of Oncology (2016) 27 (6): 68-99. 10.1093/annonc/mdw365
Authors A. Meshref1, M. Mousa1, M. Ramadan2, M.Y. Haggag3
  • 1Faculty Of Medicine, Suez Canal University, 41522 - Ismailia/EG
  • 2Faculty Of Pharmacy, Suez Canal University, 41522 - Ismailia/EG
  • 3Faculty Of Medicine, Suez Canal University, 42524 - Ismailia/EG

Abstract

Background

Estrogen and progesterone receptors have important role in management of breast cancer. Our study aim to evaluate the effect of radiotherapy with different estrogen and progesterone receptors status.

Methods

SEER database used to obtain patient data. All 18 SEER registries were used to estimate five-year relative survival rates of non-metastatic breast cancer cases with negative lymph node infiltration patient who received radiotherapy (RT) between 1998 and 2007 by Kaplan-Meir method. We compared relative survival rates among groups of patients categorized by estrogen and progesterone receptors status.

Results

200535 patient who met selection criteria in SEER database was divided into 9 groups depending on estrogen (ER) and progesterone (PR) receptor status ]positive (+), negative (-) or borderline (b)[. The result showed that there was significant difference in five-years relative survival rate in patient who received RT comparing with patient who didn't receive RT in ER+ & PR+ ]100% & 98.5% (95% CI:98.1-98.8) respectively[ (P value >0.001), ER+ & PR- ]100% & 95.1% (95% CI:94.2-95.8) respectively[ (P value >0.001), ER- & PR+ ]97.6% (95% CI:95.6-98.7) & 92% (95% CI:89.7-93.8) respectively[ (P value >0.001), ER- & PR- ]93.8% (95% CI:93.3-94.2) & 91.5% (95% CI:87.5-88.7) respectively[ (P value >0.001), ERb & PR- ]97.5% (95% CI:79.5-99.7) & 90.4% (95% CI:78.8-95.8) respectively[ (P value =0.028) & ERb & PRb ]98.5% (95% CI:31.6-100) & 84% (95% CI:73.2-90.7) respectively[ (P value =0.003) groups. The study showed that ER+ status has 100% five years relative survival rate with all PR receptor status.

Conclusions

RT is highly recommended in patient with ER+ regardless the status of PR receptor status. Also it is recommended in previous sub group which showed significant difference between patients who received RT comparing with patients who didn't receive RT.

Clinical trial identification

Legal entity responsible for the study

The Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute

Funding

None

Disclosure

All authors have declared no conflicts of interest.