1561P - Survival is associated with circulating cytokine levels in metastatic testicular germ cell tumors

Date 10 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Translational Research
Presenter Daniela Svetlovska
Citation Annals of Oncology (2016) 27 (6): 526-544. 10.1093/annonc/mdw392
Authors D. Svetlovska1, V. Miskovska2, D. Cholujova3, P. Gronesova3, S. Cingelova4, M. Chovanec5, Z. Sycova-Mila5, J. Obertova6, P. Palacka6, J. Rajec6, K. Kalavska7, V. Usakova8, J. Luha9, D. Ondrus2, S. Spanik10, J. Mardiak6, M. Mego11
  • 1Clinical Trials; Translational Research Unit, National Cancer Institute; Faculty of Medicine, Comenius University, 83310 - Bratislava/SK
  • 21st Department Of Oncology, Faculty of Medicine and St. Elisabeth Cancer Institute, Bratislava/SK
  • 3Laboratory Of Tumor Immunology, Cancer Research Institute, Slovak Academy of Sciences, Bratislava/SK
  • 4Oncohematology Clinic, National Cancer Institute, Bratislava/SK
  • 5Clinical Oncology, National Cancer Institute, Bratislava/SK
  • 6Clinical Oncology; 2nd Department Of Oncology, National Cancer Institute; Faculty of Medicine, Comenius University, Bratislava/SK
  • 7Translational Research Unit, faculty of Medicine, Comenius University, Bratislava/SK
  • 8Internal Medicine, St. Elisabeth Cancer Institute, Bratislava/SK
  • 9Institute Of Medical Biology, Genetics And Clinical Genetics, faculty of Medicine, Comenius University, Bratislava/SK
  • 101st Department Of Oncology; Internal Medicine, Faculty of Medicine and St. Elisabeth Cancer Institute; St. Elisabeth Cancer Institute, Bratislava/SK
  • 11Clinical Oncology; Translational Research Unit; 2nd Department Of Oncology, National Cancer Institute; Faculty of Medicine, Comenius University, Bratislava/SK

Abstract

Background

Cytokines are the communicators of immune system and are involved in almost all immune responses. They have an important role in cancer pathogenesis. The aim of this study was to investigate the association between plasma cytokines and patient's/tumor characteristics and prognosis in metastatic chemonaive testicular germ cell tumors (TGCTs).

Methods

The study population consisted of 92 chemonaive metastatic TGCTs patients, enrolled between July 2010 and March 2014. We analyzed 51 plasma cytokines at baseline before chemotherapy administration (n = 92) and on cycle 1 day 22 (n = 55) using multiplex bead arrays. Patients were treated with at least one cycle of cisplatin-based chemotherapy. Circulating cytokine levels were correlated with tumor characteristics, progression-free and overall survival as well.

Results

Median age was 32.4 (range 18.4-65.4) years, median follow up was 33.2 month (range 0.1-54.8). Disease progression experienced 10.9 % and 7.6 % of patients died. Several baseline cytokines positively correlated with histology, disease stage, localization of metastases. Elevated baseline levels of IFN-alpha 2, IL-2R alpha, IL-16, HGF, MCP-3 significantly correlated with worse progression-free survival (PFS) and overall survival (OS) as well, SCGF-beta only with worse OS. Higher levels of IL-12p40 measured on day 22 cycle 1 correlated with shorter PFS and OS.

Conclusions

The present study found out significant associations between circulating cytokines and prognosis and tumour/patient's characteristics in metastatic TGCTs. Our findings suggest, that plasma cytokines could be considered as biomarker for identification of high risk patients. In addition, new treatment approaches targeted for relevant cytokine should be investigated.

Clinical trial identification

Not applicable

Legal entity responsible for the study

National Cancer Institute, Bratislava, Slovak Republic

Funding

Slovak Research and Development Agency

Disclosure

All authors have declared no conflicts of interest.