625P - Surgically treated esophageal cancer developed in a radiated field: Impact on peri-operative and long-term outcomes

Date 08 October 2016
Event ESMO 2016 Congress
Session Poster Display
Topics Oesophageal Cancer
Presenter Sheraz Markar
Citation Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371
Authors S.R. Markar1, C. Gronnier2, A. Pasquer3, A. Duhamel4, H. Behal4, J. Thereaux5, J. Gagniere6, G. Lebreton7, C. Brigand8, B. Meunier9, D. Collet10, C. Mariette2
  • 1Department Of Surgery & Cancer, St Mary's Hospital, Imperial College, W21NY - London/GB
  • 2Dpt Of Digestive And Oncological Surgery, Lille University Hospital, France, 59037 - Lille/FR
  • 3Dpt Of Digestive Surgery, Hopital Edouard Herriot Pav. E bis, Lyon/FR
  • 4Department Of Biostatistics, DRC / CHRU of Lille, Lille/FR
  • 5Dpt Of Digestive Surgery, Cavale Blanche University Hospital, Brest/FR
  • 6Dpt Of Digestive Surgery, CHU Estaing, Clermont-Ferrand/FR
  • 7Dpt Of Digestive Surgery, Côte de Nacre University Hospital, Caen/FR
  • 8Dpt Of Digestive Surgery, C.H.U. Hautepierre, Strasbourg/FR
  • 9Dpt Of Digestive Surgery, CHU de Pontchaillou, Rennes/FR
  • 10Department Of Oeso-gastric And Endocrine Surgery, Centre Magellan Hôpital Haut-Lévêque, 33600 Pessac - Bordeaux/FR



The objectives of this study were to compare peri-operative and long-term outcomes from esophageal cancer (EC) (i) that arose in a previously radiated field (ECRF) versus primary (PEC) and among ECRF patients (ii) radiotherapy-induced (RIEC) versus non radiotherapy-induced EC (NRIEC).


Data was collected from 30 European centers from 2000–2010. 2489 EC patients surgically treated were included in the PEC group and 136 in the ECRF group, including 61 in the NRIEC group and 75 in the RIEC group. Propensity score matching analyses were used to compensate for differences in baseline characteristics.


Compared to the PEC group, the ECRF group was characterized by less use of neoadjuvant chemoradiotherapy (0% vs. 29.5%; P 


ECRF is associated with poorer long-term survival related to a reduced utilization of neoadjuvant chemoradiotherapy and an increased incidence of tumor margin involvement at surgery. Outcomes are dictated by the limitations related to previous radiotherapy administration more than the radiotherapy-induced carcinogenesis.

Clinical trial identification

Not applicable

Legal entity responsible for the study





All authors have declared no conflicts of interest.