1481P - Outpatient management of cancer-associated pulmonary embolism (PE): analysis of lung carcinoma (LC) cohort from the Epiphany study

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Supportive Measures
Presenter carmen Beato
Citation Annals of Oncology (2016) 27 (6): 497-521. 10.1093/annonc/mdw390
Authors C. Beato1, L. Faez2, A. Carmona-Bayonas3, M.D. Mediano4, C. Font5, D. Calvo-Temprano6, P. Jimenez Fonseca6, A. Dominguez4, M.P. Solis Hernandez6, M. Biosca7, I. de la Haba5, M. Antonio8, O. Madriano9, A. Ramchandani10, E. Castanon Alvarez11, M.J. Martinez12, J.A. Virizuela Echaburu13, R. Otero4
  • 1Medical Oncology Unit, Hospital Nisa Castilleja de la Cuesta, 41010 - Sevilla/ES
  • 2Medical Oncology Unit, Hospital Universitario Central de Asturias, Oviedo/ES
  • 3Medical Oncology, Hospital Universitario Morales Meseguer, Murcia/ES
  • 4Medical Oncology, Hospital Universitario Virgen del Rocio, 41013 - Sevilla/ES
  • 5Medical Oncology, Hospital Clinic y Provincial de Barcelona, 08036 - Barcelona/ES
  • 6Medical Oncology, Hospital Universitario Central de Asturias, 33011 - Oviedo/ES
  • 7Medical Oncology Unit, Vall d`Hebron University Hospital Institut d'Oncologia, Barcelona/ES
  • 8Medical Oncology, Institut Catala de Oncologia, 08907 - L'Hospitalet de Llobregat, Barcelona/ES
  • 9Medical Oncology Unit, Hospital Infanta sofia, madrid/ES
  • 10Medical Oncology Unit, Hospital Universitario Insular de Gran Canaria, Las Palmas/ES
  • 11Oncology Department, Clinica Universitaria de Navarra, 31008 - Pamplona/ES
  • 12Medical Oncology Unit, Hospital Universitario Santa Lucia, Cartagena/ES
  • 13Medical Oncology, Hospital Universitario Virgen Macarena, Sevilla/ES

Abstract

Background

Clinical guidelines suggest that outpatient management of PE is an appropriate alternative in low-risk selected patients. However, this population is not adequately defined and the evidence is limited in cancer patients. Primary endpoint was the rate of success in outpatient PE management. Secondary endpoints included the analysis of complications and causes of readmission and mortality, re-thrombosis and major bleeding at 15, 30 and 90 days.

Methods

Epiphany is a Spanish multicenter ambispective and non-interventional study. It includes patients with cancer-associated PE, symptomatic and incidentally diagnosed, between October 2008 and October 2014. Patients were treated according to current international guidelines, and followed for at least 90-days. We present data from the cohort with LC.

Results

We included 1033 patients with cancer and PE of whom 797 were diagnosed as outpatients. Of these, 210 had LC and 72 (34.3%) were discharged in the first 24-hours. 95.8% were incidental diagnoses and 83.3% did not show specific symptoms. The following features were associated with the last group (p

Conclusions

Within the limitations of an ambispective series and a subgroup analyses, this study suggest that most patients with LC and PE can be managed as outpatients, especially those with incidental PE. Additional studies are needed to better define the subgroup of patients at low risk of complications.

Clinical trial identification

Legal entity responsible for the study

Virgen del Rocio University hospital

Funding

IBIS

Disclosure

All authors have declared no conflicts of interest.