691P - Neutrophil to lymphocyte ratio is a predictor of outcome in metastatic pancreatic cancer patients (MPC) treated with nab-paclitaxel and gemcitabine

Date 08 October 2016
Event ESMO 2016 Congress
Session Poster Display
Topics Pancreatic Cancer
Presenter Jole Ventriglia
Citation Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371
Authors J. Ventriglia1, A. Petrillo1, M. Huerta2, M.M. Laterza1, B. Savastano1, V. Gambardella2, G. Tirino1, L. Pompella1, A. Diana1, A. Febbraro3, T. Troiani1, M. Orditura1, A. Cervantes2, F. Ciardiello1, F. De Vita1
  • 1Medical Oncology, AOU Seconda Università degli Studi di Napoli (AOU-SUN), 80130 - Napoli/IT
  • 2Medical Oncology, Hospital Clinico Universitario de Valencia, 46010 - Valencia/ES
  • 3Medical Oncology, Ospedale "Sacro Cuore di Gesù" Fatebenefratelli, Benevento/IT

Abstract

Background

High neutrophil to lymphocyte ratio (NLR) can be a predictor of poor outcomes in various malignancies, including pancreatic cancer (PC). Based on these data, we investigated NLR as prognostic markers in MPC pts who received first-line chemotherapy with nab-paclitaxel/gemcitabine; furthermore a prognostic model using inflammatory-based scores to predict survival was planned.

Methods

We assessed 70 pts with histologically confirmed MPC who received chemotherapy with nab-paclitaxel/gemcitabine at two different European oncologic centres between January 2012 and November 2015. The cut-off for the NLR was 5. Variables assessed for prognostic correlations included age ≥ 66, sex, Karnofsky PS score, primary tumor site, baseline CA19.9 level ≥ 59xULN, 12-week decrease of CA19.9 level ≥ 50% from baseline, basal bilirubin level, baseline neutrophil to lymphocyte ratio, biliary stent implantation and liver metastasis. Survival analyses were generated according to the Kaplan-Meier method. Univariate and multivariate analyses were performed by Cox proportional hazard model.

Results

With a median follow up of 32 months, median PFS and OS were 7.0 months (95% C.I. 6.221 – 7.779) and 12 months (95% C.I. 9.926-14.074), respectively with a 12-month OS rate of 34.3%. According to NLR values, the patients were divided into two groups. Median PFS and OS were 5 months and 7 months (p= 0.02) and 7 months and 13 months (p= 0.003) in high (NLR ≥ 5) and low (NLR

Conclusions

Baseline NLR is an indipendent predictor of survival of patients with MPC receiving palliative chemotherapy and could be useful to develop a simple clinical score to identify a subgroup of patients with a low chance to benefit from chemotherapy.

Clinical trial identification

Legal entity responsible for the study

Second University of Naples

Funding

Second University of Naples

Disclosure

All authors have declared no conflicts of interest.