794P - Impact of race on survival following radical cystectomy for muscle-invasive bladder cancer (MIBC): Analysis of the US National Cancer Database (NCDB)

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Urothelial Cancers
Presenter Nazli Dizman
Citation Annals of Oncology (2016) 27 (6): 266-295. 10.1093/annonc/mdw373
Authors N. Dizman1, S.K. Pal2, R.A. Nelson3, J. Hsu2, P. Bergerot4, J. Nix5, G. Sonpavde6
  • 1Internal Medicine, Medeniyet University Göztepe Training and Research Hospital, 34732 - Istanbul/TR
  • 2Medical Oncology, City of Hope, 91010 - Duarte/US
  • 3Biostatistics, City of Hope, 91010 - Duarte/US
  • 4Medical Oncology, Universidade Federal de São Paulo, São Paulo/BR
  • 5Urology, University of Alabama at Birmingham Hospital, 35294-3280 - Birmingham/US
  • 6Medical Oncology, University of Alabama at Birmingham Hospital, 35294-3280 - Birmingham/US

Abstract

Background

The impact of race as an independent factor on overall survival (OS) following radical cystectomy (RC) for muscle invasive bladder cancer (MIBC) is unclear. Small retrospective studies suggest an unfavorable impact of black race on outcomes. We conducted a retrospective analysis of the large NCDB database to evaluate the impact of race, specifically African American race, in patients undergoing RC for MIBC.

Methods

The NCDB was employed including patients (pts) with new diagnoses of urothelial carcinoma of bladder who underwent RC in the US from 2004-2013. Those with prior malignancy and prior radiotherapy were excluded. Race status was collected as white (W), black (B), white Hispanic (H) and Asian or Pacific islander (API). Multivariate analyses were conducted to determine whether race conferred an independent impact on OS in 3 separate cohorts: those who underwent RC alone, those who underwent neoadjuvant chemotherapy (NC) and those who underwent adjuvant chemotherapy (AC) after controlling for baseline stage (clinical stage for NC group, and pathologic stage for RC and AC groups), age, year of diagnosis, Charlson Comorbidity Index (CCI), number of lymph nodes examined at RC and gender.

Results

A total of 31,619 pts were available for analysis: 18,939 in the RC group (W = 17,117, B = 1075, H = 481, API = 266), 4059 in the AC group (W = 3672, B = 236, H = 107, API = 44) and 8621 in the NC group (W = 7848, B = 445, H = 204, API = 124). On multivariate analysis, black race was statistically significantly and independently associated with poor OS compared to white race in the RC alone (HR = 1.17, p = 0.0004), AC (HR = 1.32, p = 0.0007) and NC (HR = 1.21, p = 0.0034) groups. Limitations of a retrospective analysis apply.

Conclusions

Black race was validated to be an independently significant poor prognostic factor for OS in this large cohort of pts with bladder cancer undergoing RC with or without perioperative chemotherapy. The incorporation of race in post-operative nomograms and prognostic models is warranted to improve risk stratification.

Clinical trial identification

Legal entity responsible for the study

City of Hope

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.