1392P - Geographical differences in preventable cancers in Turkey

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Bioethics, Legal, and Economic Issues
Presenter Deniz Yuce
Citation Annals of Oncology (2016) 27 (6): 474-482. 10.1093/annonc/mdw387
Authors D. Yuce1, M. Hayran1, S. Eser2, S. Uner2
  • 1Preventive Oncology, Hacettepe University Cancer Institute, 06100 - Ankara/TR
  • 2Epidemiology, Hacettepe University Public Health Institute, Ankara/TR

Abstract

Background

Carcinogenic changes occur due to interactions between genetic, lifestyle-related, and environmental factors. Anti-cancer efforts should evaluate preventable risk factors to maintain a healthy life. Tobacco and obesity are the major preventable causes of cancer. We aimed to evaluate the contribution of them on cancer burden in Turkey.

Methods

Population-attributable fractions were calculated according to Peto-Lopez, and Comparative Risk Assessment Collaborative Group Methods. Geographical distributions of PAFs were analyzed with ArcMap 10.4 GIS software. Tobacco- and obesity-related cancers were determined according to IARC, and WCRF reports, respectively. Sex-specific relative risks were obtained from CPS-II, and standardized meta-analysis estimates and the Continuous Update Project. National cancer incidences in 2013 were used for calculating PAF cases. Since a 10-years of lag time was considered for the progression of cancer for obesity, prevalence rates were obtained from National Burden of Diseases and Cost-Effectiveness-Turkey 2003 Study. Duration from tobacco exposure to cancer is higher, but no previous qualified data was present, and same study was used to obtain smoking prevalence.

Results

PAFs for tobacco and obesity were 60.4% (59.6-62.7%), and 11% (9.8-13.7%), respectively. Site-specific PAFs ranged between 29.8-91.7% and 2.2-67.9% for tobacco; and between 5.7-13.1% and 3.0-25.9% for obesity in males and females, respectively. PAFs showed geographical distribution variations. Western and southern parts of Turkey were found to have greater numbers of preventable cancers. PAFs of tobacco- and obesity-related cancers

Tobacco (PAF %) Obesity (PAF %)
M F M F
Oral cavity 83.00 41.78 Colon 10.96 5.98
Oesophageus 73.99 54.28 Rectum 5.69 3.01
Stomach 32.16 5.96 Gall bladder 12.43 13.07
Pancreas 39.28 18.02 Pancreas 7.35 5.98
Larynx 87.04 67.89 Kidney 13.05 17.21
Lung 91.66 67.28 Postmenopausal breast - 7.72
Kidney 45.93 4.85 Endometrium - 25.88
Bladder 52.85 17.67 Ovary - 3.59
Leukemia 29.81 2.24
Cervix - 9.40

Conclusions

Determining possible interactions between geographical factors, distribution of risk factors, and prevalent cancers should guide preventive tasks against this important public health problem. According to our results western and southern parts of Turkey have the largest preventable numbers of tobacco and obesity related cancers.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.