1585P - Differences in incidence and biological characteristics between Roma and non-Roma women with breast cancer in Slovakia

Date 10 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Pathology/Molecular Biology
Presenter Maria Reckova
Citation Annals of Oncology (2016) 27 (6): 545-551. 10.1093/annonc/mdw393
Authors M. Reckova1, J. Mardiak2, L. Plank3, M. Vulevova4, S. Cingelova2, M. Mego2
  • 1Oncology, POKO Poprad, 058 01 - Poprad/SK
  • 2Medical Oncology, National Cancer Institute(Národný Onkologický Ustav), 83310 - Bratislava/SK
  • 3Pathology, Comenius University in Bratislava, Jessenius Faculty of Medicine, Martin/SK
  • 4Faculty Of Pharmacy, Comenius University Bratislava, POKO Poprad, Bratislava/SK

Abstract

Background

Roma (Gypsies) constitute the largest ethnic minority in Slovakia. They originally came from Northern India. There are some data about higher prevalence of communicable diseases and higher infant and childhood mortality in Roma (R). Data about non-communicable diseases are very sparse and data about cancer in R are practically non-existent. The aim of this study was to compare differences in incidence and pathological characteristics between R and non-Roma (non-R) breast cancer patients (pts) in Slovakia.

Methods

Roma and non-Roma breast cancer (BC) pts were identified using Slovak HER2 Registry that contains pathological data of all BC pts diagnosed in Slovakia from 2003. Database from the last Census of Slovakia in 2011 (C/2011) was matched by gender, date of birth and residency with HER2 Registry from 2011 to 2013. Based on the match, R and non-R breast cancer pts were identified. Age-distribution and pathological characteristics were compared between R and non-R BC pts.

Results

There were 10,344 pts registered in the HER2 Registry from 2011 to 2013, and 151,128 people identified themselves as to have Roma nationality or to speak Roma language based on the C/2011. By matching the C/2011 and HER2 Registry, 32 and 5,775 women with BC were identified as R and non-R, respectively. Median age of R pts was statistically significantly lower compared to non-R (49 vs. 61 years of age, P 

Conclusions

We, for the first time, revealed differences in incidence and biological characteristics of Roma women with BC when compared to non-Roma. Roma patients are younger at diagnosis, have higher age-standardized breast cancer incidence rate and more aggressive tumors when compared to non-Roma. Further trials are needed to identify the factors responsible for our observation.

Clinical trial identification

Legal entity responsible for the study

2nd Oncology Clinic, Faculty of Mediciine Comenius University Bratislava

Funding

2nd Oncology Clinic, Faculty of Mediciine Comenius University Bratislava

Disclosure

All authors have declared no conflicts of interest.