1193P - Comparison of combined chemoradiotherapy regimens; Paclitaxel plus carboplatin and cisplatin plus etoposide for locally advanced non-small-cell lun...

Date 08 October 2016
Event ESMO 2016 Congress
Session Poster Display
Topics Surgical Oncology
Non-Small Cell Lung Cancer
Radiation Oncology
Presenter Alper Ata
Citation Annals of Oncology (2016) 27 (6): 411-415. 10.1093/annonc/mdw382
Authors A. Ata1, A. Küçük2, E. Nayir3, Ş. Eskici2
  • 1Medical Oncology, Medical Park Hospital, 33000 - Mersin/TR
  • 2Radiation Oncology, Mersin State Hospital, Mersin/TR
  • 3Medical Oncology, Necip Fazıl State Hospital, Kahramanmaraş/TR



The optimal chemotherapy regimen to use with radiotherapy in stage III non–small-cell lung cancer (NSCLC) is unknown. This phase III comparative randomized trial was conducted to determine the optimal chemotherapy regimen with standard daily concurrent thoracic radiation therapy (CTRT), in patients with locally advanced unresected stage III NSCLC.


We recruited 108 patients aged 18–72 years with stage III, histologically confirmed NSCLC, an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2, an estimated life expectancy of greater than 3 months, and adequate organ function from January 2011 to December 2014. Patients were randomised (1:1) to paclitaxel plus carboplatin and cisplatin plus etoposide arms.


Patients with unresected stages IIIA and IIIB NSCLC received carboplatin (AUC = 2) and paclitaxel (45 mg/m2) given weekly with CTRT (63 Gy) followed by two cycles of consolidation therapy (carboplatin AUC = 6, paclitaxel 200 mg/m2) (arm CP) and cisplatin (50 mg/m2 on days 1, 8, 29, and 36) plus etoposide (50 mg/m2 daily on days 1 to 5, and 29 to 33) with CTRT followed by consolidation cisplatin plus etoposide (arm EP) were included. Ninety nine eligible patients were evaluated. With median follow-up time of 39.4 months, median overall survival was 17.1 and 16.6 months for arms CP and EP, respectively (P = 0.279). But patients in arm EP, compared with patients in arm CP, had more grade 4 neutropenia (18.1% vs 11.1%, p 


In patients with stage III NSCLC treated with cisplatin plus etoposide and carboplatin plus paclitaxel had similar overall survival, but cisplatin plus etoposide arm was associated with increased toxicity.

Clinical trial identification

Legal entity responsible for the study



Turkish Oncology Group


All authors have declared no conflicts of interest.