1379P - Clinicians identify high need to increase their genomic literacy to applied cancer genomics

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Bioethics, Legal, and Economic Issues
Presenter Janessa Laskin
Citation Annals of Oncology (2016) 27 (6): 474-482. 10.1093/annonc/mdw387
Authors J. Laskin1, D. Ha2, T. Chan3, A. Fok4, K.A. Gelmon1, A. Charters2, R. Yoshizawa2, S. Struve2, C. Ho1, D. Renouf1, H. Lim1, C. Simmons1, S. Taylor5, A. Tinker1, J. McGhie6, S. Jones4, M. Marra4, P. Chow-White2
  • 1Medical Oncology, British Columbia Cancer Agency, V5Z 4E6 - Vancouver/CA
  • 2School Of Communications, Simon Fraser, Vancouver/CA
  • 3Medical Oncology, British Columbia Cancer Agency, Vancouver/CA
  • 4Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver/CA
  • 5Medical Oncology, BC Cancer Agency, Kelowna/CA
  • 6Medical Oncology, British Columbia Cancer Agency-Vancouver Island Centre, Victoria/CA

Abstract

Background

This study is the first survey of the genomic literacy of medical oncologists as co-investigators on a trial using medical genomic “big data”. The Personalized Onco-Genomics Program (POG) conducts whole genome DNA and RNA sequencing and in-depth bioinformatic analyses on patients with metastatic cancers to identify somatic variants and gene expression changes that may be targetable cancer “drivers”. Aberrant pathways are matched to drug databases and this data is reported to the clinician for each individual patient.

Methods

We conducted a survey of medical oncologists based at the six tertiary care cancer hospitals of the BC Cancer Agency (n = 31, 52.5% response rate) who enroll patients into POG. We measured oncologists' level of genomic knowledge and their experience and attitudes about genomic science and technologies.

Results

We found a low to moderate level of genomic literacy amongst the oncologists as 48% reported having little knowledge about newer genetic/genomic technologies. Clinicians outside of the Vancouver area (the major urban centre) reported having less knowledge about new genetics technologies compared to those located in the Vancouver area (26.7% vs 73.3%, P 

Conclusions

The data suggests a high need to increase genomic literacy amongst oncologists beginning in medical school and with ongoing educational tools. Although these oncologists had variable experiences with POG directly informing treatment decisions; there was overall agreement that genomics and big data will play an increasingly important role in cancer care decision-making.

Clinical trial identification

Not applicable

Legal entity responsible for the study

BC Cancer Agency

Funding

BC Cancer Foundation

Disclosure

J. Laskin: Academic talk honoraria: AZ, Roche. Research grants to institution from: BI, Lilly and Roche. C. Ho: Honoraria AZ, Bayer, BMS, BI, Pfizer, Lilly, Roche. Research grants BI, Genzyme. Travel grant BI. D. Renouf: Honoraria from Celgene. H. Lim: Honoraria/Consulting/Research Funding: Eli Lilly, Leo, Bayer, Ipsen, Amgen. All other authors have declared no conflicts of interest.