890P - Cervical cancer: Awareness and misconceptions of risk factors among lay persons and physicians

Date 08 October 2016
Event ESMO 2016 Congress
Session Poster Display
Topics Cervical Cancer
Presenter Xavier Pivot
Citation Annals of Oncology (2016) 27 (6): 296-312. 10.1093/annonc/mdw374
Authors X. Pivot1, J. Morère2, S. Couraud3, C. Touboul4, J. Blay5, A.B. Cortot6, C. Lhomel7, F. Eisinger8, L. Greillier9, J. Viguier10
  • 1Service Oncologie Medicale, CHU Besançon, Hôpital Jean Minjoz, 25030 - Besançon/FR
  • 2Medical Oncology, Hopital Paul Brousse, 94800 - Villejuif/FR
  • 3Respiratory Diseases And Thoracic Oncology, Centre Hospitalier Lyon Sud, 69495 - Pierre Bénite/FR
  • 4Statistics, KantarHealth, Paris/FR
  • 5Medical Oncology, Centre Léon Bérard, Lyon/FR
  • 6Pneumology And Thoracic Oncology, DRC / CHRU of Lille, Lille/FR
  • 7Oncology/hematology Institutionnal, Roche, Boulogne-Billancourt/FR
  • 8Cancer Control, Institute Paoli Calmettes, Marseille/FR
  • 9Multidisciplinary Oncology And Therapeutic Innovations, Hopital Nord, Marseille/FR
  • 10Medical Oncology, CHRU Bretonneau, 37044 - Tours/FR



Cervical cancer (CC) is the fourth most common cancer in women worldwide. Human papillomavirus (HPV) subtypes 16 and 18 account for 70% of cases of CC. 80% of sexually active French women are infected by HPV at least once in their lifetime. Vaccination and screening are the main weapons against CC. This branch of the EDIFICE survey focuses on awareness of CC risk factors among the lay population and physicians.


The 4th nationwide observational survey was conducted by phone interviews using the quota method. A representative sample of 737 women (age, 40-75 yrs) was interviewed between June 12 and July 10, 2014. A mirror survey on a representative sample of 105 female physicians was conducted between July 9 and August 8, 2014. Interviewees were asked to cite the five main risk factors for CC.


For 30.3% of lay population participants, heredity/family history was the main CC risk factor while 39.0% of physicians (non-significant difference, NS) ranked it second after other factors related to sexually-transmitted infections (STI) and risky sexual behavior. STI were cited by 85.7% of the physicians; notably, 76.2% also mentioned HPV whereas these risk factors were cited by only 21.7% and 8.0% of the lay population (P 


Although not a recognized risk factor for CC, heredity/family history was ranked first by lay persons and second by physicians. Physicians were largely aware of HPV as a major risk factor for CC. They also widely cited notorious risky sexual behavior associated with the risk of contracting HPV, and tobacco, a known cofactor. Lay persons however, were inadequately aware of these risk factors. Other recognized cofactors such as the pill or multiple pregnancies were cited far less frequently both by physicians and lay persons.

Clinical trial identification

Legal entity responsible for the study

Edifice surveys were funded by Roche S.A.


Edifice surveys were funded by Roche S.A.


X. Pivot, J-F. Morère, S. Couraud, J-Y. Blay, A.B. Cortot, F. Eisinger, L. Greillier: Honorarium fees from Roche. C. Lhomel: Employee of Roche. All other authors have declared no conflicts of interest.