1009P - A novel treatment of radiation induced xerostomia by autologous platelet-rich-plasma and peripheral stem cells

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Head and Neck Cancers
Presenter Ali Taghizadeh Kermani
Citation Annals of Oncology (2016) 27 (6): 328-350. 10.1093/annonc/mdw376
Authors A. Taghizadeh Kermani1, P. Izadpanahi1, K. Khazaeni1, M. Pezeshki Rad M2, R. Asadi1, M. Asadi1, D. Hamidi Alamdari3
  • 1Oncology Department, cancer research center, 9176613775 - Mashhad/IR
  • 2Radiology Department, cancer research center, 9176613775 - Mashhad/IR
  • 3Stem Cell Laboratory, Biochemistry and Nutrition Research Center, 9176613775 - Mashhad/IR

Abstract

Background

There are 30000 to 40000 head and neck cancers cases in United States each year. Radiotherapy is one of the best treatment options in these patients. Unfortunately, Xerostomia is one of most common side effects. This study aimed to evaluate effect of autologous platelet rich plasma (PRP) and PRP along with peripheral blood cells (PC) application in treatment of radiation induced xerostomia for the first time in the world.

Methods

21 patients with head and neck cancers who suffered from post radiation xerostomia were selected regard to inclusion criteria. Patients were divided into PRP or PRP + PC group randomly. They were followed up for 6 months. Data was analyzed by SPSS version 20 and parametric and nonparametric tests

Results

21 patients with the age between 20 and 61 years were entered the pilot study. 47.6% were female and other was male. Mean left parotid uptake to back ground (first month after injection) in PRP and RPR + PC group was 0.31 ± 1.6 and 1.3± 0.62 and this difference was significant (P = 0.33). This index in right submandibul (sixth month after injection) was -0.31 ± 0.43 and 1.3 ± 1.2 (P = 0/033). All quality of life parameters show improvement in first and sixth month after treatment (P 

Conclusions

All quality of life parameters show improvement after treatment and these findings were qualified by objective results of Scintigraphy scan. Absorption parameters in Scintigraphy show significant improvement in all salivary glands. Secretion parameters show significant improvement in both parotid glands not sub mandibular glands. These may be due to small sample size or short follow up period. Result of scan showed that PRP + PC are more effective than RPR

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

Mashhad University of Medical Sciences

Disclosure

All authors have declared no conflicts of interest.