315P - Radial scar, a retrospective study of 202 cases: Development of a predictive score to assess breast carcinoma association

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Surgical oncology
Breast Cancer
Therapy
Radiation oncology
Presenter Sarah Rikelman
Citation Annals of Oncology (2014) 25 (suppl_4): iv85-iv109. 10.1093/annonc/mdu327
Authors S. Rikelman1, A.E. Dugue2, S. Giacchetti3, A. De Roquancourt4, F. Joly-Lobbedez5, C. Levy6, H. Crouet7, J. Lebrun7
  • 1Surgery, centre francois baclesse, 14000 - caen/FR
  • 2Clinical Research, Centre Francois Baclesse, 14000 - CAEN/FR
  • 3Oncology, APHP St Louis, paris/FR
  • 4Anathomopathology, APHP St Louis, paris/FR
  • 5Clinical Research, Centre Francois Baclesse, CAEN/FR
  • 6Sénologie, Centre François BACLESSE, Caen/FR
  • 7Surgery, centre francois baclesse, caen/FR

Abstract

Aim

To assess the rate of breast carcinoma associated with Radial Scar (RS) and to identify risk factors of this association. The secondary objective was to build a carcinoma prediction score associated with RS.

Methods

This is a retrospective study including 202 patients with histologically confirmed RS. The study was performed on electronic medical records from 1986 to 2012, in the anti-cancer center François Baclesse in Caen, France. Two subgroups of lesions were studied as a function of the final histological results: RS associated with or without carcinoma. Clinical, histological and radiological data were studied as possible risk factors.

Results

Two hundred patients were operated. In total, 126 (63%) were pure RS, 26 (13%) were associated with atypical hyperplasia, 26 (13%) with in situ carcinoma, and 22 (11%) with invasive carcinoma. The mean age of patients with RS + carcinoma was significantly higher than patients without carcinoma (57 versus 51.1 years, p = 0.001). The median size of RS with carcinoma tended to be higher than without carcinoma (10 versus 8mm, p = 0.07). We built a score, considering age, RS size and mammographic criteria to classify patients at low (score= 0), medium (score from 1 to 5) or high risk (score > 5) of in situ or invasive carcinoma, with risk of carcinomas respectively 0%, 20% and 64%, p = 0.0005.

Conclusions

RS is rare but may be associated with carcinoma. This lesion should undergo a preoperative biopsy. The advanced age of the patient and the large size of the lesion appear to be correlated with a higher risk of association between RS and carcinoma. The development of our carcinoma prediction score could help us to optimize patients' care. This score must be validated in a prospective study.

Disclosure

All authors have declared no conflicts of interest.