870P - Impact of histopathologic variants on survival of patients with metastatic urothelial carcinoma

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Urothelial Cancers
Pathology/Molecular Biology
Basic Scientific Principles
Presenter Yu-Li Su
Citation Annals of Oncology (2014) 25 (suppl_4): iv280-iv304. 10.1093/annonc/mdu337
Authors Y. Su
  • Division Of Hematology-oncology, Kaohsiung Chang Gung Memorial Hospital, 833 - Kaohsiung/TW



The aim of our study was to investigate the clinical and prognostic impact of histopathologic variants of metastatic urothelial carcinoma patients treated with systemic chemotherapy.


A retrospective analysis of the in-hospital database was performed in Kaohsiung Chang Gung Memorial Hospital for the period January 1997 to December 2013. We enrolled a total of 206 patients who received systemic chemotherapy for metastatic urothelial carcinoma. Histopathologic types were categorized as pure urothelial carcinoma (PUC; n = 151) or variants of urothelial carcinoma (VUC, n = 55). We analyzed overall survival (OS) and progression-free survival (PFS) by Kaplan-Meier analysis and Cox's proportional regression models.


The median follow-up was 25.2 months. The most common histopathologic variants were squamous differentiation that accounted for 72% of all variants. Patients with VUC were more likely to have renal pelvis location (44% vs. 24%, p = 0.004) and chronic renal insufficiency (40% vs. 23%, p = 0.02) than those with PUC. All patients received at least one-line of chemotherapy, and the most common regimens were gemcitabine/cisplatin (GC) and methotrexate/vinblastine/doxorubicin/cisplatin (MVAC). On univariable analysis, the median OS of VUC patients were significantly better then PUC patients (16.2 vs. 11.2 months, p = 0.003). The median PFS of first-line chemotherapy were 6.2 months and 4.0 months for PUC and VUC, respectively (p = 0.004). On multivariable analysis, patients with VUC showed independently decreased OS compared with those with PUC (HR 1.54, 95% CI 1.03-2.3, p = 0.035).


In metastatic urothelial carcinoma patients treated with chemotherapy, histopathologic variants showed a significant role in predicting worse survival than pure urothelial carcinoma.


All authors have declared no conflicts of interest.